The Amazon Region of Ecuador (ARE) hosts a great variety of biodiversity and ecosystems. These hotspots are internationally recognized for presenting unique fauna and flora found nowhere else in the world. Within the ARE, there is the Yasuní National Park (YNP), a recognized Biosphere Reserve located in the sub-basins of various rivers. The study area is the “ITT Oil Block” (Ishpingo, Tambococha, and Tiputini), situated in the Province of Orellana and superimposed on the YNP. The block has an area of 179,449.53 ha. The main objective of the current study was to analyze the multi-temporality of land-use change in the ITT Oil Block of the ARE. In the methodological process, the PCI Geomatic and ARCGIS programs were used for the processing and classification of satellite images (Landsat 7 and 8). The changes in land use in the ITT Oil Block over the three periods (2001, 2014, and 2017) indicated that forest cover decreased by 24.23% in soils, while infrastructure and cultivation increased throughout the time period by 0.27% and 0.23%, respectively. The most significant land-use change rate in the ITT Oil Block in the period 2001–2017 are the categories of bare soil with 9.01% (10,640.82 ha) and cultivation with 7.27% (591.29 ha).
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