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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/59264

    Título
    Age and sex-adjusted reference intervals in tear cytokine levels in healthy subjects
    Autor
    Fernández Martínez, ItziarAutoridad UVA Orcid
    Enriquez De Salamanca Aladro, AmaliaAutoridad UVA Orcid
    Portero, Alejandro
    García Vázquez, Carmen
    Calonge, MargaritaAutoridad UVA Orcid
    Herreras Cantalapiedra, José MaríaAutoridad UVA Orcid
    Año del Documento
    2021
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Applied Science, 2021, vol. 11, n. 19, 8958
    Zusammenfassung
    Alterations in tear cytokine levels have been associated with various ocular disorders as compared to those in healthy subjects. However, age and sex are not always considered in these comparisons. In this study we aimed to establish age and sex reference intervals (RIs) for tear cytokine levels in healthy people. Tear samples were taken from 75 males and 82 females, aged 18–88 years, and tear cytokine levels were determined. Age- and sex-adjusted RIs for epidermal growth factor (EGF), fractalkine, interleukin (IL)-1 receptor antagonist (RA), IL-7, IL-8, interferon inducible protein (IP)-10, monocyte chemotactic protein (MCP)-1, and vascular endothelial growth factor (VEGF) tear cytokine levels in a healthy sample were established using generalized additive for location, scale and shape (GAMLSS) models. RIs were tested in two external samples: a validation sample of 40 individuals with normal results at four Dry Eye Disease (DED) clinical diagnostic tests (OSDI, T-BUT, corneal staining and Schirmer test); and a utility sample of 13 severe DED cases. IL-1RA, IL-8, IP-10, and MCP-1 levels showed a positive association with age, while EGF was negatively correlated. IL-7 concentration increased up to 40 years and again after 70 years, observing a quasi-linear decrease between them. For VEGF, higher levels were observed in the middle-aged range. Regarding sex-influence, fractalkine tear levels were higher in men, whereas those of IL-7, IL-8, and IP-10 were higher in women. Using the estimated age- and sex-adjusted RIs, more than 92% of the validation sample was correctly classified, and 100% of the severe DED patients in the utility sample had concentrations outside the RIs in at least two of the cytokines evaluated.
    Materias (normalizadas)
    Ophthalmology
    Ojo Enfermedades y defectos
    Materias Unesco
    3201.09 Oftalmología
    Palabras Clave
    Tear cytokines
    Biomarkers
    Age- and sex-influence
    Dry eye disease
    Citocinas lagrimales
    Biomarcadores
    Influencia de la edad y el sexo
    Enfermedad del ojo seco
    Revisión por pares
    SI
    DOI
    10.3390/app11198958
    Version del Editor
    https://www.mdpi.com/2076-3417/11/19/8958
    Propietario de los Derechos
    © 2021 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/59264
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • IOBA - Artículos de revista [82]
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    Dateien zu dieser Ressource
    Nombre:
    Age-and-Sex-Adjuste-Reference-Intervals.pdf
    Tamaño:
    4.062Mb
    Formato:
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    Universidad de Valladolid

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