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Título
Study of different chiral columns for the enantiomeric separation of azoles using supercritical fluid chromatography
Autor
Año del Documento
2023
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Separations, 2023, Vol. 10, Nº. 1, 9
Abstract
The enantiomeric separation of antifungal compounds is an arduous task in pharmaceutical and biomedical fields due to the different properties that each diastereoisomer presents. The enantioseparation of a group of fungicides (sulconazole, bifonazole, triadimefon and triadimenol) using supercritical fluid chromatography was achieved in this work. For this goal, four different chiral columns based on polysaccharide derivatives, as well as the effect of different chromatographic parameters such as temperature, type and percentage of organic modifier (methanol, ethanol and isopropanol), were thoroughly investigated. The inversion of the elution order of enantiomers as a result of a change in the stationary phase or organic modifier was also evaluated by employing a circular dichroism detector. The best separation conditions, in terms of the enantioresolution and analysis time, were obtained with the Lux® Cellulose-2 column using isopropanol as the organic modifier.
Materias (normalizadas)
Enantiomers - Separation
Pharmacology
Supercritical fluid chromatography
Cromatografía en fase líquida
Antifungal agents - Therapeutic use
Fungicidas
Chromatographic analysis
Chiral drugs - Separation
Separation (Technology)
Separación (Tecnología)
Materias Unesco
2301 Química Analítica
3209 Farmacología
Revisión por pares
SI
Version del Editor
Propietario de los Derechos
© 2022 The Authors
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
Collections
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