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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/61852

    Título
    Association of the APOA-5 genetic variant rs662799 with metabolic changes after an intervention for 9 months with a low-calorie diet with a Mediterranean profile
    Autor
    Luis Román, Daniel Antonio deAutoridad UVA Orcid
    Primo Martín, David
    Izaola Jauregui, OlatzAutoridad UVA
    Aller de la Fuente, RocíoAutoridad UVA Orcid
    Año del Documento
    2022
    Editorial
    MDPI
    Descripción
    Producción Científica
    Documento Fuente
    Nutrients, 2022, Vol. 14, Nº. 12, 2427
    Abstract
    In cross-sectional studies, the genetic variant rs662799 of the APOA5 gene is associated with high serum triglyceride concentrations, and in some studies, the effect of short-term dietary interventions has been evaluated. The aim of the present investigation was to evaluate the role of this genetic variant in metabolic changes after the consumption of a low-calorie diet with a Mediterranean pattern for 9 months. A population of 269 Caucasian obese patients was recruited. Adiposity and biochemical parameters were measured at the beginning (basal level) and after 3 and 9 months of the dietary intervention. The rs662799 genotype was assessed with a dominant analysis (TT vs. CT + CC). The APOA5 variant distribution was: 88.1% (n = 237) (TT), 11.5% (n = 31) (TC) and 0.4% (n = 1) (CC). There were significant differences only in triglyceride levels at all times of the study between the genotype groups. After 3 and 9 months of dietary intervention, the following parameters improved in both genotype groups: adiposity parameters, systolic pressure, total cholesterol, LDL cholesterol, leptin, adiponectin and the leptin/adiponectin ratio. The intervention significantly decreased insulin levels, HOMA-IR and triglyceride levels in non-C allele carriers (Delta 9 months TT vs. TC + CC). i.e., insulin levels (delta: −3.8 + 0.3 UI/L vs. −1.2 + 0.2 UI/L; p = 0.02), HOMA-IR levels (delta: −1.2 + 0.2 units vs. −0.3 + 0.1 units; p = 0.02), triglyceride levels (delta: −19.3 + 4.2 mg/dL vs. −4.2 + 3.0 mg/dL; p = 0.02). In conclusion, non-C allele carriers of rs662799 of the APOA5 gene showed a decrease of triglyceride, insulin and HOMA-IR levels after consuming a low-calorie diet with a Mediterranean pattern; we did not observe this effect in C allele carriers, despite a significant weight loss.
    Materias (normalizadas)
    Human genetics
    Genética humana
    Regímenes alimentarios
    Nutrition
    Nutrición
    Dietetics
    Dietética
    Diet therapy
    Diet
    Dieta
    Food Science
    Triglycerides
    Triglicéridos
    Materias Unesco
    3206 Ciencias de la Nutrición
    32 Ciencias Médicas
    ISSN
    2072-6643
    Revisión por pares
    SI
    DOI
    10.3390/nu14122427
    Version del Editor
    https://www.mdpi.com/2072-6643/14/12/2427
    Propietario de los Derechos
    © 2022 The Authors
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/61852
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP52 - Artículos de revista [181]
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