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Título
Supercritical foaming and impregnation of polycaprolactone and polycaprolactone-hydroxyapatite composites with carvacrol
Autor
Año del Documento
2022
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Processes, 2022, Vol. 10, Nº. 3, 482
Abstract
Polycaprolactone (PCL) and polycaprolactone-hydroxyapatite (PCL-HA) scaffolds were produced by foaming in supercritical carbon dioxide (scCO2) at 20 MPa, as well as in one-step foaming and impregnation process using carvacrol as an antibacterial agent with proven activity against Gram-positive and Gram-negative bacteria. The experimental design was developed to study the influence of temperature (40 °C and 50 °C), HA content (10 and 20 wt.%), and depressurization rate (one and two-step decompression) on the foams’ morphology, porosity, pore size distribution, and carvacrol impregnation yield. The characterization of the foams was carried out using scanning electron microscopy (SEM, SEM-FIB), Gay-Lussac density bottle measurements, and Fourier–transform infrared (FTIR) analyses. The obtained results demonstrate that processing PCL and PCL-HA scaffolds by means of scCO2 foaming enables preparing foams with porosity in the range of 65.55–74.39% and 61.98–67.13%, at 40 °C and 50 °C, respectively. The presence of carvacrol led to a lower porosity. At 40 °C and one-step decompression at a slow rate, the porosity of impregnated scaffolds was higher than at 50 °C and two- step fast decompression. However, a narrower pore size distribution was obtained at the last processing conditions. PCL scaffolds with HA resulted in higher carvacrol impregnation yields than neat PCL foams. The highest carvacrol loading (10.57%) was observed in the scaffold with 10 wt.% HA obtained at 50 °C.
Materias (normalizadas)
Supercritical carbon dioxide
Supercritical CO2
Carbon dioxide
Dióxido de carbono
Polycaprolactone
Polymers
Biodegradable
Hydroxyapatite
Scaffold
Foam
Espumas poliméricas
Carvacrol
Antibacterial agents
Antiinfecciosos
Materias Unesco
3303 Ingeniería y Tecnología Químicas
2206.10 Polímeros
ISSN
2227-9717
Revisión por pares
SI
Patrocinador
Narodowe Centrum Nauki (Polonia) - (grant 2018/31/B/ ST8/01826)
Agencia Nacional de Investigación y Desarrollo de Chile (ANID) - (project 120130)
Programa de Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia - (Project AFB180001)
Agencia Nacional de Investigación y Desarrollo de Chile (ANID) - (project 120130)
Programa de Financiamiento Basal para Centros Científicos y Tecnológicos de Excelencia - (Project AFB180001)
Version del Editor
Propietario de los Derechos
© 2022 The Authors
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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