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Título
Cytosolic organelles shape calcium signals and exo–endocytotic responses of chromaffin cells
Autor
Año del Documento
2012
Editorial
Elsevier
Descripción
Producción Científica
Documento Fuente
Cell Calcium, 2012, vol. 51, p. 309-320
Zusammenfassung
The concept of stimulus–secretion coupling was born from experiments performed in chromaffin cells 50
years ago. Stimulation of these cells with acetylcholine enhances calcium (Ca2+) entry and this generates a
transient elevation of the cytosolic Ca2+ concentration ([Ca2+]c) that triggers the exocytotic release of catecholamines.
The control of the [Ca2+]c signal is complex and depends on various classes of plasmalemmal
calcium channels, cytosolic calcium buffers, the uptake and release of Ca2+ from cytoplasmic organelles,
such as the endoplasmic reticulum, mitochondria, chromaffin vesicles and the nucleus, and Ca2+ extrusion
mechanisms, such as the plasma membrane Ca2+-stimulated ATPase, and the Na+/Ca2+ exchanger.
Computation of the rates of Ca2+ fluxes between the different cell compartments support the proposal
that the chromaffin cell has developed functional calcium tetrads formed by calcium channels, cytosolic
calcium buffers, the endoplasmic reticulum, and mitochondria nearby the exocytotic plasmalemmal sites.
These tetrads shape the Ca2+ transients occurring during cell activation to regulate early and late steps of
exocytosis, and the ensuing endocytotic responses. The different patterns of catecholamine secretion in
response to stress may thus depend on such local [Ca2+]c transients occurring at different cell compartments,
and generated by redistribution and release of Ca2+ by cytoplasmic organelles. In this manner,
the calcium tetrads serve to couple the variable energy demands due to exo–endocytotic activities with
energy production and protein synthesis.
Materias (normalizadas)
Calcio
Bioquímica
ISSN
0143-4160
Revisión por pares
SI
Idioma
eng
Derechos
openAccess
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