Diet could be both culprit and solution of NAFLD. Dietary modifications have been
associated with histological features improvement in NAFLD. The Western diet was
related to a greater risk of disease progression while theMediterranean diet (MD) could
promote regression of histological lesions. Modifications in the nutrient composition
seems to have lesser impact on NAFLD than dietary modifications. An intrinsic
interaction between nutrients in the diet support a specific effect not seen when
added separately. Dietary modifications should focus on promoting weight loss but
also look for patterns that are able to promote histological improvement. Although
several micronutrients’ deficit has been related to NAFLD progression, prescribing
these micronutrients’ supplementation did not reach a positive impact. However, an
enriching diet with specific nutrients could be useful, like olive oil supplemented inMD.
Geometry of nutrition defines a framework to better understand the interaction
between nutrients, foods, and dietetic pattern in the model of diseases and how we
could approach taking into consideration the interaction between meals and disease
features. After analyzing baseline diet and histological lesions, we could calculate the
distance to optimal diet and to promote changes in lifestyle to reach all these goals. A
standard MD menu would be recommended.
