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Título
Is the conjunctiva a potential target for advanced therapy medicinal products?
Año del Documento
2021
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Pharmaceutics, 2021, vol. 13, n. 8, 1140
Abstract
The conjunctiva is a complex ocular tissue that provides mechanical, sensory, and immune protection for the ocular surface. It is affected by many diseases through different pathological mechanisms. If a disease is not treated and conjunctival function is not fully restored, the whole ocular surface and, therefore, sight is at risk. Different therapeutic approaches have been proposed, but there are still unsolved conjunctival alterations that require more sophisticated therapeutic options. Advanced therapy medicinal products (ATMPs) comprise a wide range of products that includes cell therapy, tissue engineering, and gene therapy. To the best of our knowledge, there is no commercialized ATMP specifically for conjunctival treatment yet. However, the conjunctiva can be a potential target for ATMPs for different reasons. In this review, we provide an overview of the advances in experimental phases of potential ATMPs that primarily target the conjunctiva. Important advances have been achieved through the techniques of cell therapy and tissue engineering, whereas the use of gene therapy in the conjunctiva is still marginal. Undoubtedly, future research in this field will lead to achieving commercially available ATMPs for the conjunctiva, which may provide better treatments for patients.
Materias (normalizadas)
Oftalmología
Materias Unesco
3201.09 Oftalmología
Palabras Clave
Advanced therapies
Conjunctiva
Tissue engineering
Terapias avanzadas
Conjuntiva
Ingeniería Tisular
Revisión por pares
SI
Patrocinador
Ministerio de Ciencia e Innovación y Ministerio de Universidades - AEI-FEDER (RTI2018–094071- B-C2)
Version del Editor
Propietario de los Derechos
© 2021 The Authors
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
Collections
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Except where otherwise noted, this item's license is described as Atribución 4.0 Internacional