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Título
The Role of Ca2+ Signaling in Aging and Neurodegeneration: Insights from Caenorhabditis elegans Models
Autor
Año del Documento
2020
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Cells, Enero 2020, 9, 204
Résumé
Ca2+ is a ubiquitous second messenger that plays an essential role in physiological processes such as muscle contraction, neuronal secretion, and cell proliferation or differentiation. There is ample evidence that the dysregulation of Ca2+ signaling is one of the key events in the development of neurodegenerative processes, an idea called the “calcium hypothesis” of neurodegeneration. Caenorhabditis elegans (C. elegans) is a very good model for the study of aging and neurodegeneration. In fact, many of the signaling pathways involved in longevity were first discovered in this nematode, and many models of neurodegenerative diseases have also been developed therein, either through mutations in the worm genome or by expressing human proteins involved in neurodegeneration (beta -amyloid, alpha-synuclein, polyglutamine, or others) in defined worm tissues. The worm is completely transparent throughout its whole life, which makes it possible to carry out Ca2+ dynamics studies in vivo at any time, by expressing Ca2+ fluorescent probes in defined worm tissues, and even in specific organelles such as mitochondria. This review will summarize the evidence obtained using this model organism to understand the role of Ca2+ signaling in aging and neurodegeneration.
Palabras Clave
Ca2+; C. elegans; neurodegeneration; Alzheimer; Parkinson; SERCA; IP3 receptor; ryanodine receptor
ISSN
2073-4409
Revisión por pares
SI
Patrocinador
MICINN project BFU2017-83509-R
Junta de Castilla y León project VA011G18
Junta de Castilla y León project VA011G18
Version del Editor
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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