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dc.contributor.authorBachiller, Alejandro
dc.contributor.authorLubeiro, Alba
dc.contributor.authorDíez, Álvaro
dc.contributor.authorSuazo, Vanessa
dc.contributor.authorDomínguez, Cristina
dc.contributor.authorBlanco, José A.
dc.contributor.authorAyuso, Marta
dc.contributor.authorHornero, Roberto
dc.contributor.authorPoza, Jesús
dc.contributor.authorMolina, Vicente
dc.date.accessioned2024-02-28T20:19:18Z
dc.date.available2024-02-28T20:19:18Z
dc.date.issued2014
dc.identifier.citationEuropean Archives of Psychiatry and Clinical Neuroscience 265(6): 525-35es
dc.identifier.issn0940-1334es
dc.identifier.urihttps://uvadoc.uva.es/handle/10324/66455
dc.description.abstractThe analysis of the interaction between novelty and relevance may be of interest to test the aberrant salience hypothesis of schizophrenia (SCH). In comparison with other neuroimaging techniques, such as functional magnetic resonance imaging, electroencephalography (EEG) provides high temporal resolution. Therefore, EEG is useful to analyze transient dynamics in neural activity, even in the range of milliseconds. In this study, EEG activity from 31 patients with SCH and 38 controls was analyzed using Shannon spectral entropy (SE) and median frequency (MF). The aim of the study was to quantify differences between distractor (i.e., novelty) and target (i.e., novelty and relevance) tones in an auditory oddball paradigm. Healthy controls displayed a larger SE decrease in response to target stimulus than in response to distractor tones. SE decrease was accompanied by a significant and widespread reduction of MF (i.e., a significant slowing of EEG activity). In comparison with controls, patients showed a significant reduction of changes in SE in response to both target and distractor tones. These differences were also observed in patients that only received a minimal treatment prior to EEG recording. Furthermore, significant changes in SE were inversely correlated to positive and total symptoms severity for SCH patients. Our findings support the notion that SCH is associated with a reduced response to both novelty and relevance during an auditory P300 task.es
dc.format.mimetypeapplication/pdfes
dc.language.isospaes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.titleDecreased entropy modulation of EEG response to novelty and relevance in schizophrenia during a P300 taskes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1007/s00406-014-0525-5es
dc.identifier.publicationfirstpage525es
dc.identifier.publicationissue6es
dc.identifier.publicationlastpage535es
dc.identifier.publicationtitleEuropean Archives of Psychiatry and Clinical Neurosciencees
dc.identifier.publicationvolume265es
dc.peerreviewedSIes
dc.identifier.essn1433-8491es
dc.type.hasVersioninfo:eu-repo/semantics/draftes


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