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Título
Potentiation by cyclooxygenase inhibitors of the release of catecholamines from the rabbit carotid body and its reversal by prostaglandin E2
Año del Documento
1992
Editorial
Elsevier
Descripción
Producción Científica
Documento Fuente
Neuroscience Letters, 1992, vol. 140 p.1-4
Zusammenfassung
Salicylates, at the high therapeutic doses used in the treatment of rheumatoid arthritis, produce an increase in ventilation and augment the carotid
body reactivity to hypoxic stimulus, leading to an exaggerated hyperventilation during hypoxia. These effects had been related to the action of
salicylates as uncouplers of oxidative phosphorylation. In the present study, carried out in an in vitro preparation of the rabbit carotid body, we show
that acetylsalicylic acid and indomethacin, two anti-inflammatory drugs that are also powerful inhibitors of cyclooxygenase, the prostaglandinsynthetizing
enzyme, produce an increase in the [3H]catecholamine release evoked by low oxygen stimulation. The drugs did not affect basal normoxic
release, a finding that suggests that at the concentration used these anti-inflammatory agents do not have uncoupling actions, and that their effects
on hypoxic-induced release of [3H]catecholamines is mediated by their specific action as cyclooxygenase inhibitors. In agreement with this suggestion
we found that prostaglandin E~ completely prevented the effects of both anti-inflammatory agents. In addition, our data indicate that endogenously
synt hetized prostaglandins are powerful modulators of chemoreceptor cell function.
Materias (normalizadas)
Artritis reumatoide - Tratamiento
ISSN
0304-3940
Revisión por pares
SI
Idioma
eng
Derechos
openAccess
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