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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/6825

    Título
    Effects of 2-Deoxy-D-Glucose on In Vitro Cat Carotid Body
    Autor
    Obeso Cáceres, Ana María de la LuzAutoridad UVA Orcid
    Almaraz Gómez, LauraAutoridad UVA
    González Martínez, Constancio
    Año del Documento
    1986
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Brain Research 371(1986) 25-36
    Résumé
    The process of chemosensory transduction in the arterial chemoreceptors is not well understood. According to the metabolic hypothesis of chemoreception, a decrease in arterial pO 2 will produce a decrease in the adenosine triphosphate (ATP) content in the chcmosensory type I cells, leading to release of a neurotransmitter and increased sensory neural activity. There is a paucity of direct experimental support for this hypothesis, and in the present work, we have tested the postulates of the metabolic hypothesis in an in vitro preparation of cat carotid body using 2-deoxy-D-glucose as an ATP-depleting agent. This preparation, when superfused with Tyrode containing 5 mM Na+-pyruvate instead of glucose, responds normally to hypoxia, low pH and acetylcholinc, and maintains normal ATP levels. Under these conditions, 2-deoxy-D-glucose is a chemostimulant, i.e. electrical activity in the carotid sinus nerve is increased, with a threshold concentration of 0.25 mM and a maximum response at about 2-4 raM. These concentrations of 2-deoxyglucose evoke a dose-dependent release of [3H]dopamine (synthesized from pH]tyrosine) from the carotid bodies which parallels the electrical activity. The 2-deoxy-D-glucose-evoked release and electrical activity is dependent on the presence of extracellular Ca 2+ . These same concentrations of 2-deoxy-D-glucose significantly reduce the ATP content of the carotid bodies. The events postulated bv the metabolic hypothesis, i.e. decrease in ATP content, release of a putative neurotransminer and activation of the sensory nerve endings are found to occur simultaneously. A possible cause-effect relationship between these three events is discussed.
    Materias (normalizadas)
    Neurofisiología
    ISSN
    00006-8993
    Revisión por pares
    SI
    DOI
    10.1016/0006-8993(86)90806-1
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/6825
    Derechos
    openAccess
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    • DEP06 - Artículos de revista [353]
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    Constancio 7.pdf
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