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    Por favor, use este identificador para citar o enlazar este ítem:https://uvadoc.uva.es/handle/10324/70772

    Título
    Thermally Induced Matrix Tension in Temperature-Sensitive Elastin-Like Hydrogels Influences Cellular Behavior
    Autor
    Rodríguez Alonso, Pablo
    Director o Tutor
    Rodríguez Méndez, María LuzAutoridad UVA
    Santos García, María MercedesAutoridad UVA
    Editor
    Universidad de Valladolid. Facultad de CienciasAutoridad UVA
    Año del Documento
    2024
    Titulación
    Máster en Nanociencia y Nanotecnología Molecular
    Abstract
    Mechanical effects on cells play a crucial role in cellular behavior and function, influencing processes such as proliferation, differentiation, and migration. Elastin-like recombinamers (ELRs) are a class of biomaterials known for their unique thermosensitivity, exhibiting reversible phase transitions in response to temperature changes. This study employs biofunctional temperature-sensitive ELRs to create hydrogels that contract upon heating at physiological temperature, generating intrinsic tension within the hydrogel matrix when the hydrogel is mechanically prevented from shrinking. This innovative approach allows for the decoupling of stress and strain and their influence on cell behavior, providing a unique platform to examine cellular responses to anisotropic tensioned matrices that remain undeformed despite the thermally-driven emerging stress. The results demonstrate that cells on the tensioned hydrogels exhibit oriented growth, aligning with the lines of tension present in the hydrogel. Additionally, the tension within the matrix seems to favor cellular proliferation. These findings, particularly the observation that cells react differently on stressed and unstressed samples despite not being deformed themselves, reveal novel insights into cellular mechanobiology. This enhances the understanding of mechanical interactions between cells and the extracellular matrix. This knowledge holds significant potential for advancements in tissue engineering, regenerative medicine, and the development of biomaterial-based scaffolds.
    Palabras Clave
    Biomateriales
    Mecanobiología
    Elastina
    Departamento
    Departamento de Química Física y Química Inorgánica
    Departamento de Química Orgánica
    Idioma
    eng
    URI
    https://uvadoc.uva.es/handle/10324/70772
    Derechos
    embargoedAccess
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    • Trabajos Fin de Máster UVa [7034]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternacionalLa licencia del ítem se describe como Attribution-NonCommercial-NoDerivatives 4.0 Internacional

    Universidad de Valladolid

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