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Título
Spermine attenuates carotid body glomus cell oxygen sensing by inhibiting
Autor
Año del Documento
2011
Editorial
Elsevier
Descripción
Innovación Educativa
Documento Fuente
Respiratory Physiology & Neurobiology 175 (2011) 80–89
Résumé
An increase in intracellular Ca2+ is crucial to O2 sensing by the carotid body. Polyamines have been
reported to modulate both the extracellular Ca2+-sensing receptor (CaR) and voltage-gated Ca2+ channels
in a number of cell types. Using RT-PCR and immunohistochemistry, the predominant voltage-gated Ca2+
channels expressed in the adult rat carotid body were L (CaV1.2) and N (CaV2.2)-type. CaR mRNA could
not be amplified from carotid bodies, but the protein was expressed in the nerve endings. Spermine
inhibited the hypoxia-evoked catecholamine release from isolated carotid bodies and attenuated the
depolarization- and hypoxia-evoked Ca2+ influx into isolated glomus cells. In agreement with data from
carotid body, recombinant CaV1.2 was also inhibited by spermine. In contrast, the positive allosteric
modulator of CaR, R-568, was without effect on hypoxia-induced catecholamine release from carotid
bodies and depolarization-evoked Ca2+ influx into glomus cells. These data show that spermine exerts a
negative influence on carotid body O2 sensing by inhibiting L-type Ca2+ channels.
Materias (normalizadas)
Respiración celular
ISSN
1569-9048
Revisión por pares
Sí
Idioma
eng
Derechos
openAccess
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