Pillow stuffing can contain polyester, feathers, down, or, more recently, soy-based materials. Component-resolved diagnosis and microarray technology might be useful in patients with foodsensitized allergies or anaphylaxis caused by hidden allergens.
We report 4 patients with repeated anaphylaxis, which was defined as a decrease in blood pressure and possibly lifethreatening adverse reactions1 during sleep at home but not in other places. Patient 1 was a 64-year-old woman with previous nocturnal rhinitis who began to experience anaphylaxis during sleep. Patient 2 was a 58-year-old man with progressive rhinitis, asthma, and anaphylaxis after changing his bedroom furniture and bed linen. Patient 3 was a 64-year-old woman with previous sensitization to Anisakis simplex and nocturnal pharyngeal angioedema unrelated to eating fish or other sources of A simplex who experienced severe anaphylaxis during sleep. Patient 4 was a 69-year-old woman with nocturnal anaphylaxis for 1 year before diagnosis
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