RT info:eu-repo/semantics/article
T1 IFNL3 rs12980275 polymorphism predicts septic shock-related death in patients undergoing major surgery: A retrospective study
A1 Pérez García, Felipe
A1 Jiménez Sousa, María Ángeles
A1 Soria, Susana
A1 Jorge Monjas, Pablo
A1 Fernández Rodríguez, Amanda
A1 Gómez Sánchez, Esther
A1 Heredia Rodríguez, María
A1 Gómez Pesquera, Estefanía
A1 Martínez de Paz, Pedro José
A1 Tamayo Gómez, Eduardo
A1 Resino, Salvador
K1 Septic shock
K1 Shock séptico
K1 Major surgery
K1 Cirugía mayor
AB Interferon lambda 3 (IFNL3, previously called IL-28B) is a cytokine with effects against viral and bacterial pathogens. We aimed to analyze the IFNL3 rs12980275 SNP in patients who underwent major surgery, in order to establish its relationship with susceptibility to septic shock and septic shock-related death in these patients. We performed a case-control study on 376 patients to establish the association between IFNL3 rs12980275 SNP and the susceptibility to develop septic shock. Besides, we performed a longitudinal study among 172 septic shock patients using survival analysis with one censoring point of 28-days mortality. The IFNL3 rs12980275 polymorphism was genotyped by Agena Bioscience's MassARRAY platform. IFNL3 rs12980275 polymorphism was not associated with higher susceptibility to infection and septic shock development. Regarding survival analysis, the Kaplan–Meier analysis showed that patients with IFNL3 rs12980275 AA genotype had higher survival than patients with GG genotype (p = 0.003). The Cox regression analysis adjusted by the most relevant clinical and epidemiological characteristics showed that the GG genotype (recessive model) and the presence of the G allele (additive model) were associated with higher risk of death [adjusted hazard ratio (aHR) = 2.15, p = 0.034; aHR = 1.50, p = 0.030, respectively]. In conclusion, IFNL3 rs12980275 polymorphism was associated with septic shock-related death in patients who underwent major surgery. The A allele was linked to protection, and the G allele was associated with an increased risk of death. This is a first preliminary study that suggests for the first time a role of IFNL3 polymorphisms in the prognosis of septic shock.
PB Frontiers
SN 2296-858X
YR 2020
FD 2020
LK http://uvadoc.uva.es/handle/10324/45464
UL http://uvadoc.uva.es/handle/10324/45464
LA eng
NO Frontiers in Medicine, 2020, vol. 7. 7 p.
NO Producción Científica
DS UVaDOC
RD 15-may-2024