RT info:eu-repo/semantics/article
T1 IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study
A1 Jiménez Sousa, María Ángeles
A1 Medrano, Luz María
A1 Liu, Pilar
A1 Fernández Rodríguez, Amanda
A1 Almansa Mora, Raquel
A1 Gómez Sánchez, Esther
A1 Ortega, Alicia
A1 Heredia Rodríguez, María
A1 Gómez Pesquera, Estefanía
A1 Tamayo Gómez, Eduardo
A1 Resino, Salvador
K1 Interleukin-6
K1 Interleucina-6
K1 Single nucleotide polymorphism
K1 Polimorfismo de nucleótido único
K1 Septic shock
K1 Choque séptico
K1 Major surgery
K1 Cirugía mayor
AB Background: Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection, being the primary cause of death from infection, especially if not recognized and treated promptly. The aim of this study was to analyze whether IL-6 rs1800795 polymorphism is associated with septic shock-related death in European white patients who underwent major surgery. Methods: We performed a retrospective study on 202 septic shock patients who underwent major cardiac or abdominal surgery. The septic shock was established according to the international septic shock definition. The primary outcome variable was the death within 90 days after diagnosis of septic shock. The IL-6 rs1800795 polymorphism was genotyped by Sequenom’s MassARRAY platform. Results: The median age of the patients was 73 years, 63.4% were male, and more than 40% of patients had heart disease and hypertension. Overall, the survival analysis showed that 111 (55%) patients died with a survival median of 39 days (95% CI 30.7; 47.2). The genetic analysis association with survival was performed under a recessive genetic model (CC vs. GG/CG). Patients with IL-6 rs1800795 CC genotype had higher mortality rate than the IL-6 rs1800795 GG/CG genotype at days 7 [31.6% (6/19) vs. 10.4% (19/183); log-rank test (p = 0.005)] and 28 [57.9% (11/19) vs. 33.3% (61/183); log-rank test (p = 0.009)], and 90 [68.4% (13/19) vs. 53.5% (98/183); log-rank test (p = 0.006)]. The IL-6 rs1800795 CC genotype was associated with higher risk of septic shock-related death during the first 7 days [adjusted hazard ratio (aHR 4.65; p = 0.002), 28 days (aHR 2.50; p = 0.006), and 90 days (aHR 2.28; p = 0.006)] with septic shock. When patients were stratified by type of surgery, those with IL-6 rs1800795 CC genotype who underwent cardiac surgery had higher risk of death during the first 7 days (aHR 18.39; p = 0.001) and 28 days (aHR 6.1; p = 0.025) than IL-6 rs1800795 GG/GC carrier, whereas patients with IL-6 rs1800795 CC genotype who underwent abdominal surgery had higher risk of death during all follow-up (aHR 1.98; p = 0.050) than IL-6 rs1800795 GG/GC carrier. Conclusions: The presence of IL-6 rs1800795 CC genotype was associated with higher risk of septic shock-related death in patients who underwent major cardiac or abdominal surgery. These findings need robust validation in bigger independent cohorts.
PB Springer
SN 2110-5820
YR 2017
FD 2017
LK http://uvadoc.uva.es/handle/10324/45488
UL http://uvadoc.uva.es/handle/10324/45488
LA eng
NO Annals of Intensive Care, 2017, vol. 7. 9 p.
NO Producción Científica
DS UVaDOC
RD 18-may-2024