RT info:eu-repo/semantics/article
T1 Complex morphogenesis by a model intrinsically disordered protein
A1 González Obeso, Constancio
A1 González Pérez, Miguel
A1 Mano, João
A1 Alonso Rodrigo, Matilde
A1 Rodríguez Cabello, José Carlos
AB The development of intricate and complex self-assembling structures in themicrometer range, such as biomorphs, is a major challenge in materialsscience. Although complex structures can be obtained from self-assemblingmaterials as they segregate from solution, their size is usually in thenanometer range or requires accessory techniques. Previous studies withintrinsically disordered proteins (IDPs) have shown that the active interplayof different molecular interactions provides access to new and more complexnanostructures. As such, it is hypothesized that enriching the variety ofintra- and intermolecular interactions in a model IDP will widen the landscapeof sophisticated intermediate structures that can be accessed. In thisstudy, a model silk-elastin-like recombinamer capable of interacting via threenon-covalent interactions, namely hydrophobic, ion-pairing, and H-bondingis built. This model material is shown to self-assemble into complex stablemicrometer-sized biomorphs. Variation of the block composition, pH, andtemperature demonstrates the necessary inte
PB Advanced Science News
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/47854
UL https://uvadoc.uva.es/handle/10324/47854
LA spa
NO Small 2020, 16, 2005191
NO Producción Científica
DS UVaDOC
RD 20-may-2024