RT info:eu-repo/semantics/article
T1 Structural brain changes in patients with persistent headache after COVID-19 resolution
A1 Planchuelo Gómez, Álvaro
A1 García Azorín, David
A1 Guerrero Peral, Angel Luis
A1 Rodríguez, Margarita
A1 Aja Fernández, Santiago
A1 Luis García, Rodrigo de
K1 COVID-19
K1 Headache
K1 Gray matter
K1 Diffusion tensor imaging
K1 Migraine
K1 32 Ciencias Médicas
AB Headache is among the most frequently reported symptoms after resolution of COVID-19. We assessed structural brainchanges using T1- and diffusion-weighted MRI processed data from 167 subjects: 40 patients who recovered from COVID-19 but suffered from persistent headache without prior history of headache (COV), 41 healthy controls, 43 patients withepisodic migraine and 43 patients with chronic migraine. To evaluate gray matter and white matter changes, morphometryparameters and diffusion tensor imaging-based measures were employed, respectively. COV patients showed significantlower cortical gray matter volume and cortical thickness than healthy subjects (p < 0.05, false discovery rate corrected) in theinferior frontal and the fusiform cortex. Lower fractional anisotropy and higher radial diffusivity (p < 0.05, family-wise errorcorrected) were observed in COV patients compared to controls, mainly in the corpus callosum and left hemisphere. COVpatients showed higher cortical volume and thickness than migraine patients in the cingulate and frontal gyri, paracentrallobule and superior temporal sulcus, lower volume in subcortical regions and lower curvature in the precuneus and cuneus.Lower diffusion metric values in COV patients compared to migraine were identified prominently in the right hemisphere.COV patients present diverse changes in the white matter and gray matter structure. White matter changes seem to be associ-ated with impairment of fiber bundles. Besides, the gray matter changes and other white matter modifications such as axonalintegrity loss seemed subtle and less pronounced than those detected in migraine, showing that persistent headache afterCOVID-19 resolution could be an intermediate state between normality and migraine.
PB Springer
SN 0340-5354
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/57049
UL https://uvadoc.uva.es/handle/10324/57049
LA eng
NO Journal of Neurology, 2022.
NO Producción Científica
DS UVaDOC
RD 17-may-2024