RT info:eu-repo/semantics/article
T1 Clinical profile, treatment and predictors during the first COVID-19 wave: a population-based registry analysis from Castile and Leon hospitals
A1 Gutiérrez Abejón, Eduardo
A1 Tamayo Gómez, Eduardo
A1 Martín García, Débora
A1 Álvarez González, Francisco Javier
A1 Herrera Gómez, Francisco Magno
K1 SARS (Disease)
K1 COVID-19
K1 Enfermedades por virus - Tratamiento
K1 Mortalidad
K1 Novel respiritory viral diseases
K1 Nephrology
K1 Riñones -  Enfermedades
K1 2420 Virología
AB The first wave of the COVID-19 pandemic collapsed the hospitals in Castile and Leon (Spain). An analysis of the clinical characteristics, drug therapies and principal outcome predictors in the COVID-19 hospitalized patients from 1 March to 31 May 2020 is presented through a population-based registry study. Hospital stay variables, ventilation mode data and clinical outcomes were observed. In Castile and Leon hospitals, 7307 COVID-19 patients were admitted, with 57.05% being male and a median of 76 years. The mortality rate was 24.43%, with a high incidence of severe acute respiratory syndrome (SARS) (14.03%) and acute kidney injury (AKI) (10.87%). The most used medicines were antibiotics (90.83%), antimalarials (42.63%), steroids (44.37%) and antivirals, such as lopinavir/ritonavir (42.63%). The use of tocilizumab (9.37%) and anti-SIRS (systemic inflammatory response syndrome) medicines (7.34%) were remarkable. Fundamentally, death occurred more likely over 65 years of age (OR: 9.05). In addition, the need for ventilation was associated with a higher probability of death (OR: 3.59), SARS (OR: 5.14) and AKI (OR: 2.31). The drug-use pattern had been modified throughout the COVID-19 first wave. Multiple factors, such as age, gender and the need for mechanical ventilation, were related to the worst evolution prognosis of the disease.
PB MDPI
SN 1660-4601
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/58902
UL https://uvadoc.uva.es/handle/10324/58902
LA eng
NO International Journal of Environmental Research and Public Health. 2020, Vol.17, Nº. 24,  9360
NO Producción Científica
DS UVaDOC
RD 25-may-2024