RT info:eu-repo/semantics/article
T1 Matrix metalloproteinases in age-related macular degeneration (AMD)
A1 García Onrubia, Luis
A1 Valentín Bravo, Francisco Javier
A1 Coco Martín, Rosa María
A1 González Sarmiento, Rogelio
A1 Pastor Jimeno, José Carlos
A1 Usategui Martín, Ricardo
A1 Pastor Idoate, Salvador
K1 Retinal degeneration - Age factors
K1 Degeneracion macular
K1 Extracellular matrix
K1 Metalloproteinases
K1 Ojos - Enfermedades
K1 Bruch’s membrane
K1 3201.09 Oftalmología
AB Age-related macular degeneration (AMD) is a complex, multifactorial and progressive retinal disease affecting millions of people worldwide. In developed countries, it is the leading cause of vision loss and legal blindness among the elderly. Although the pathogenesis of AMD is still barely understood, recent studies have reported that disorders in the regulation of the extracellular matrix (ECM) play an important role in its etiopathogenesis. The dynamic metabolism of the ECM is closely regulated by matrix metalloproteinases (MMPs) and the tissue inhibitors of metalloproteinases (TIMPs). The present review focuses on the crucial processes that occur at the level of the Bruch’s membrane, with special emphasis on MMPs, TIMPs, and the polymorphisms associated with increased susceptibility to AMD development. A systematic literature search was performed, covering the years 1990–2020, using the following keywords: AMD, extracellular matrix, Bruch’s membrane, MMPs, TIMPs, and MMPs polymorphisms in AMD. In both early and advanced AMD, the pathological dynamic changes of ECM structural components are caused by the dysfunction of specific regulators and by the influence of other regulatory systems connected with both genetic and environmental factors. Better insight into the pathological role of MMP/TIMP complexes may lead to the development of new strategies for AMD treatment and prevention.
PB MDPI
SN 1661-6596
YR 2020
FD 2020
LK https://uvadoc.uva.es/handle/10324/58964
UL https://uvadoc.uva.es/handle/10324/58964
LA eng
NO International Journal of Molecular Sciences, 2020, Vol. 21, Nº.16,  5934
NO Producción Científica
DS UVaDOC
RD 07-jun-2024