RT info:eu-repo/semantics/doctoralThesis
T1 Análisis de supervivencia e Identificación de factores pronósticos tras cirugía curativa de metástasis hepáticas de cáncer colorrectal.
A1 Plúa Muñiz, Katherine Teresa
A2 Universidad de Valladolid. Escuela de Doctorado
K1 Hígado - Metástasis
K1 liver metastasis
K1 Metástasis hepáticas
K1 Survival analysis
K1 Supervivencia
K1 32 Ciencias Médicas
AB INTRODUCTIONLiver resection is the only curative treatment for colorectal liver metastasis (CRLM). The identification of predictive factors leads to personalize patient management to enhance their long-term outcomes. This population-based study aimed to characterize factors associated with, and survival impact of patients who received hepatectomy for colorectal liver metastasis (CRLM). PATIENTS AND METHODSA retrospective cohort study of all the hepatectomies for colorectal liver metastasis (CRLMs) performed at third-level hospital of Spain (2010-2018) was conducted. The Kaplan-Meier method was used for survival analyses. Multivariable Cox and regression models were used to determine prognostic factors associated with overall survival (OS).RESULTS The 5-year overall survival (OS) and disease-free survival (DFS) were 42 and 33%, respectively. Survival analysis showed that metastasis features (number, largest size, distribution, and extrahepatic disease) and postsurgical factors (transfusion, major complications, and positive margin resection), as well as non-mutated KRAS, showed a significant association with survival. Otherwise, on multivariate analysis, only five independent risk factors were identified: major size metastasis > 4cm, RAS mutation, positive margin resection, intraoperative transfusion, and major complications. CONCLUSIONS According to our findings, major size metastasis > 4 cm, intraoperative transfusion, and major postoperative complications continue to be traditional prognostic factors. Meanwhile, the KRAS biomarker has a powerful impact as a survival prognostic factor.
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/60809
UL https://uvadoc.uva.es/handle/10324/60809
LA spa
NO Escuela de Doctorado
DS UVaDOC
RD 10-jun-2024