RT info:eu-repo/semantics/article
T1 Ten years of experience support pharmacogenetic Testing to guide individualized drug therapy
A1 Peña Martín, María Celsa
A1 García Berrocal, Belén
A1 Sánchez Martín, Almudena
A1 Marcos Vadillo, Elena
A1 García Salgado, María Jesús
A1 Sánchez Iglesias, Santiago
A1 Lorenzo, Carolina
A1 González Parra, David
A1 Sans, Francisco
A1 Franco Martín, Manuel Ángel
A1 Gaedigk, Andrea
A1 Mateos Sexmero, María José
A1 Sanz Lozano, Catalina
A1 Isidoro García, María
K1 Pharmacogenetics
K1 Farmacogenética
K1 Polypharmacy
K1 Precision medicine
K1 Medicina personalitzada
K1 Pharmacotherapy
K1 Farmacología - Terapéutica
K1 Pharmacology/Toxicology
K1 Genetics
K1 Genetica
K1 Drugs
K1 Medicamentos
K1 32 Ciencias Médicas
K1 3209 Farmacología
K1 3214 Toxicología
AB Precision medicine utilizing the genetic information of genes involved in the metabolism and disposition of drugs can not only improve drug efficacy but also prevent or minimize adverse events. Polypharmacy is common among multimorbid patients and is associated with increased adverse events. One of the main objectives in health care is safe and efficacious drug therapy, which is directly correlated to the individual response to treatment. Precision medicine can increase drug safety in many scenarios, including polypharmacy. In this report, we share our experience utilizing precision medicine over the past ten years. Based on our experience using pharmacogenetic (PGx)-informed prescribing, we implemented a five-step precision medicine protocol (5SPM) that includes the assessment of the biological–clinical characteristics of the patient, current and past prescription history, and the patient’s PGx test results. To illustrate our approach, we present cases highlighting the clinical relevance of precision medicine with a focus on patients with a complex history and polypharmacy.
PB MDPI
SN 1999-4923
YR 2022
FD 2022
LK https://uvadoc.uva.es/handle/10324/62969
UL https://uvadoc.uva.es/handle/10324/62969
LA eng
NO Pharmaceutics, 2022, Vol. 14, Nº. 1, 160
NO Producción Científica
DS UVaDOC
RD 03-jun-2024