RT info:eu-repo/semantics/article
T1 Neurobiological underpinnings of cognitive subtypes in psychoses: A cross-diagnostic cluster analysis
A1 Fernández-Linsenbarth, Inés
A1 Planchuelo-Gómez, Álvaro
A1 Díez, Álvaro
A1 Arjona-Valladares, Antonio
A1 de Luis, Rodrigo
A1 Martín-Santiago, Óscar
A1 Benito-Sánchez, José Antonio
A1 Pérez-Laureano, Ángela
A1 González-Parra, David
A1 Montes-Gonzalo, Carmen
A1 Melero-Lerma, Raquel
A1 Morante, Sonia Fernández
A1 Sanz-Fuentenebro, Javier
A1 Gómez-Pilar, Javier
A1 Núñez-Novo, Pablo
A1 Molina, Vicente
AB Schizophrenia and bipolar disorder include patients with different characteristics, which may hamper the definition of biomarkers. One of the dimensions with greater heterogeneity among these patients is cognition. Recent studies support the identification of different patients' subgroups along the cognitive domain using cluster analysis. Our aim was to validate clusters defined on the basis of patients' cognitive status and to assess its relation with demographic, clinical and biological measurements. We hypothesized that subgroups characterized by different cognitive profiles would show differences in an array of biological data. Cognitive data from 198 patients (127 with chronic schizophrenia, 42 first episodes of schizophrenia and 29 bipolar patients) were analyzed by a K-means cluster approach and were compared on several clinical and biological variables. We also included 155 healthy controls for further comparisons. A two-cluster solution was selected, including a severely impaired group and a moderately impaired group. The severely impaired group was associated with higher illness duration and symptoms scores, lower thalamus and hippocampus volume, lower frontal connectivity and basal hypersynchrony in comparison to controls and the moderately impaired group. Moreover, both patients' groups showed lower cortical thickness and smaller functional connectivity modulation than healthy controls. This study supports the existence of different cognitive subgroups within the psychoses with different neurobiological underpinnings.
SN 0920-9964
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/63821
UL https://uvadoc.uva.es/handle/10324/63821
LA spa
NO Schizophrenia Research, Marzo 2021: 229, 102-111
DS UVaDOC
RD 16-jun-2024