RT info:eu-repo/semantics/article
T1 Lipid peroxidation as a hallmark of severity in COVID-19 patients
A1 Martín-Fernández, Marta
A1 Aller de la Fuente, Rocío
A1 Heredia-Rodríguez, María
A1 Gómez-Sánchez, Esther
A1 Martínez-Paz, Pedro
A1 Gonzalo-Benito, Hugo
A1 Sánchez-de Prada, Laura
A1 Gorgojo, Óscar
A1 Carnicero-Frutos, Irene
A1 Tamayo, Eduardo
A1 Tamayo-Velasco, Álvaro
AB Background: Oxidative stress may be a key player in COVID-19 pathogenesis due to its significant role in responseto infections. A defective redox balance has been related to viral pathogenesis developing a massive induction ofcell death provoked by oxidative stress. The aim of this study is to perform a complete oxidative stress profileevaluation regarding antioxidant enzymes, total antioxidant capacity and oxidative cell damage in order tocharacterize its role in diagnosis and severity of this disease.Methods: Blood samples were obtained from 108 COVID-19 patients and 28 controls and metabolites representative of oxidative stress were assessed. The association between lipid peroxidation and 28-day intubation/deathrisk was evaluated by multivariable regression analysis. Probability of intubation/death to day-28 was analyzedby using Kaplan-Meier curves and tested with the log-rank test.Results: Antioxidant enzymes (Superoxide dismutase (SOD) and Catalase) and oxidative cell damage (Carbonyland Lipid peroxidation (LPO)) levels were significantly higher in COVID-19 patients while total antioxidantcapacity (ABTS and FRAP) levels were lower in these patients. The comparison of oxidative stress molecules’levels across COVID-19 severity revealed that only LPO was statistically different between mild and intubated/death COVID-19 patients. COX multivariate regression analysis identified LPO levels over the OOP(LPO>1948.17 μM) as an independent risk factor for 28-day intubation/death in COVID-19 patients [OR: 2.57;95% CI: 1.10–5.99; p = 0.029]. Furthermore, Kaplan-Meier curve analysis revealed that COVID-19 patientsshowing LPO levels above 1948.17 μM were intubated or died 8.4 days earlier on average (mean survival time15.4 vs 23.8 days) when assessing 28-day intubation/death risk (p < 0.001).Conclusion: These findings deepen our knowledge of oxidative stress status in SARS-CoV-2 infection, supportingits important role in COVID-19. In fact, higher lipid peroxidation levels are independently associated to a higherrisk of intubation or death at 28 days in COVID-19 patients.
PB elsevier
SN 2213-2317
YR 2021
FD 2021
LK https://uvadoc.uva.es/handle/10324/64526
UL https://uvadoc.uva.es/handle/10324/64526
LA spa
NO Redox Biol. 2021 Nov 6;48:102181
DS UVaDOC
RD 15-jun-2024