RT info:eu-repo/semantics/article
T1 The association of urine metals and metal mixtures with cardiovascular incidence in an adult population from Spain: the Hortega Follow-Up Study
A1 Domingo Relloso, Arce
A1 Grau-Perez, Maria
A1 Briongos-Figuero, Laisa
A1 Gomez-Ariza, Jose L
A1 Garcia-Barrera, Tamara
A1 Dueñas-Laita, Antonio
A1 Bobb, Jennifer F
A1 Chaves, F Javier
A1 Kioumourtzoglou, Marianthi-Anna
A1 Navas-Acien, Ana
A1 Redon-Mas, Josep
A1 Martín Escudero, Juan Carlos
A1 Tellez Plaza, Maria
K1 Urine metals, cardiovascular incidence, population-based, cohort study, BKMR
AB Background: The association of low-level exposure to metals and metal mixtures with cardiovascular incidence in the general population has rarely been studied. We flexibly evaluated the association of urinary metals and metal mixtures concentrations with cardiovascular diseases in a representative sample of a general population from Spain.Methods: Urine antimony (Sb), barium (Ba), cadmium (Cd), chromium (Cr), cobalt (Co), copper (Cu), molybdenum (Mo), vanadium (V) and zinc (Zn) were measured in 1171 adults without clinical cardiovascular diseases, who participated in the Hortega Study. Cox proportional hazard models were used for evaluating the association between single metals and cardiovascular incidence. We used a Probit extension of Bayesian Kernel Machine Regression (BKMR-P) to handle metal mixtures in a survival setting.Results: In single-metal models, the hazard ratios [confidence intervals (CIs)] of cardiovascular incidence, comparing the 80th to the 20th percentiles of metal distributions, were 1.35 (1.06, 1.72) for Cu, 1.43 (1.07, 1.90) for Zn, 1.51 (1.13, 2.03) for Sb, 1.46 (1.13, 1.88) for Cd, 1.64 (1.05, 2.58) for Cr and 1.31 (1.01, 1.71) for V. BKMR-P analysis was confirmatory of these findings, supporting that Cu, Zn, Sb, Cd, Cr and V are related to cardiovascular incidence in the presence of the other metals. Cd and Sb showed the highestposterior inclusion probabilities.Conclusions: Urine Cu, Zn, Sb, Cd, Cr and V were independently associated with increased cardiovascular risk at levels relevant for the general population of Spain. Urine metals in the mixture were also jointly associated with cardiovascular incidence, with Cd and Sb being the most important components of the mixture.
PB Oxfor University Press
SN 0300-5771
YR 2019
FD 2019
LK https://uvadoc.uva.es/handle/10324/64978
UL https://uvadoc.uva.es/handle/10324/64978
LA eng
NO International Journal of Epidemiology, Abril 2019, vol. 48, p. 1-11
NO Producción Científica
DS UVaDOC
RD 07-jun-2024