RT info:eu-repo/semantics/article
T1 Regularity analysis of nocturnal oximetry recordings to assist in the diagnosis of sleep apnoea syndrome
A1 Marcos, J. Víctor
A1 Hornero, Roberto
A1 Nabney, Ian T.
A1 Álvarez, Daniel
A1 Gutiérrez-Tobal, Gonzalo C.
A1 del Campo, Félix
AB The relationship between sleep apnoea–hypopnoea syndrome (SAHS) severity and the regularity of nocturnal oxygen saturation (SaO2) recordings was analysed. Three different methods were proposed to quantify regularity: approximate entropy (AEn), sample entropy (SEn) and kernel entropy (KEn). A total of 240 subjects suspected of suffering from SAHS took part in the study. They were randomly divided into a training set (96 subjects) and a test set (144 subjects) for the adjustment and assessment of the proposed methods, respectively. According to the measurements provided by AEn, SEn and KEn, higher irregularity of oximetry signals is associated with SAHS-positive patients. Receiver operating characteristic (ROC) and Pearson correlation analyses showed that KEn was the most reliable predictor of SAHS. It provided an area under the ROC curve of 0.91 in two-class classification of subjects as SAHS-negative or SAHS-positive. Moreover, KEn measurements from oximetry data exhibited a linear dependence on the apnoea hypopnoea index, as shown by a correlation coefficient of 0.87. Therefore, these measurements could be used for the development of simplified diagnostic techniques in order to reduce the demand for polysomnographies. Furthermore, KEn represents a convincing alternative to AEn and SEn for the diagnostic analysis of noisy biomedical signals.
PB ELSEVIER
SN 1350-4533
YR 2016
FD 2016
LK https://uvadoc.uva.es/handle/10324/65598
UL https://uvadoc.uva.es/handle/10324/65598
LA eng
NO Medical Engineering & Physics, 2016, vol. 38, n. 3, p. 216-224.
NO Producción Científica
DS UVaDOC
RD 20-may-2024