RT info:eu-repo/semantics/article
T1 25-hydroxyvitamin D serum levels linked to single-nucleotide polymorphisms (SNPs) (rs2228570, rs2282679, rs10741657) in sports performance in CrossFit® elite athletes
A1 Fernández Lázaro, Diego
A1 Celorrio San Miguel, Ana M.
A1 Seco Calvo, Jesús
A1 Roche Collado, Enrique
A1 Fernández Lázaro, César I.
K1 Sports performance
K1 Sports - Physiological aspects
K1 Deportes - Aspectos fisiológicos
K1 Vitamina D
K1 Single nucleotide polymorphisms
K1 Genetics
K1 Genética
K1 Elite athletes
K1 Deportistas profesionales
K1 Entrenamiento deportivo
K1 2302.32 Vitaminas
K1 2411.06 Fisiología del Ejercicio
AB Vitamin D substantially influences sports performance and post-exercise recovery because it offers anti-inflammatory, antioxidant and cellular protective properties. However, deficient levels of 25-hydroxyvitamin D 25(OH)D (25(OH)D) (<30 ng/mL) could impact the health of individuals, lead to musculoskeletal disorders and decrease athletic performance. Therefore, it would be appropriate to know the interactions between genes and vitamin D. We evaluated whether 25(OH)D had a possible connection to the presence of certain SNPs in CYP2R1 (rs10741657), GC (rs2282679) and muscle VDR (rs2228570) genes, with serum 25(OH)D concentrations and the degree of WOD performance in highly trained CrossFit® practitioners. Knowing these relationships could be instrumental for personalized vitamin D supplementation and training strategies. Using a standardized commercial enzyme-linked immunosorbent assay procedure, the concentrations of 25(OH)D were determined and the genotyping procedures for each SNPs were carried out using specific assays with the KASpar® test. The 25(OH)DA performance level in grades was established based on the CrossFit® Total score (sum in kilograms of one Repetition Max Squat, Press and Deadlift). Significant differences (p < 0.05) in 25(OH)D concentration were found between each of the SNPs of CYP2R1 and GC with 25(OH)D. We discovered statistically significant weak positive correlations (p < 0.05) between 25(OH)D and AA-alleles of the CYP2R1 and VDR genes, and TT-alleles of the GC gene. Additionally, AA (rs10741657 and rs2228570) and TT (rs2282679) have a probability between 2 and 4 of having major concentrations of 25(OH)D and 25(OH)D25(OH)D. Conversely, GG alleles present a probability of suboptimum values of 25(OH)D of 69%, 34% and 24% for VDR, GC and CYP2R1, respectively, showing a strong moderate positive correlation (r = 0.41) between the degrees of sports performance and 25(OH)D25(OH)D plasma levels. The different polymorphisms of our three candidate genes CYP2R1 (rs10741657), GC (rs2282679) and VDR (rs2228570) disturb 25(OH)D concentration and play a critical role in the sports performance of elite CrossFit® practitioners. These results could highlight that the evaluation of genetic factors is key to designing a vitamin D supplementation strategy to improve sports performance.
PB MDPI
SN 2673-9976
YR 2023
FD 2023
LK https://uvadoc.uva.es/handle/10324/67068
UL https://uvadoc.uva.es/handle/10324/67068
LA eng
NO Biology and Life Sciences Forum, 2023, Vol. 29, Nº. 1, 21
NO Producción Científica
DS UVaDOC
RD 03-jun-2024