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dc.contributor.author | Rodríguez Ferrer, Patricia | |
dc.contributor.author | Sanz Novo, Miguel | |
dc.contributor.author | Maestro Fernández, Alicia | |
dc.contributor.author | Andrés García, José María | |
dc.contributor.author | Pedrosa Sáez, Rafael | |
dc.date.accessioned | 2019-08-30T09:06:30Z | |
dc.date.available | 2019-08-30T09:06:30Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Advanced Synthesis and Catalysis, 2019, vol. 361, n. 15. p. 3645-3655 | es |
dc.identifier.issn | 1615-4169 | es |
dc.identifier.uri | http://uvadoc.uva.es/handle/10324/37719 | |
dc.description | Producción Científica | es |
dc.description.abstract | Enantioenriched 3‐amino‐3‐substituted oxindoles have been obtained by addition of different nucleophiles to N‐Boc ketimines derived from isatin catalyzed by chiral bifunctional supported thioureas. The Mannich reaction occurs with excellent enantioselection, but poor diastereoselection when prochiral nucleophiles were used. The supported catalyst were recovered and reused for five times without loss of activity. The mixture of diastereoisomers formed when a prochiral structure was used as nucleophile was converted into a single enantioenriched pyrazolyl derivative. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | eng | es |
dc.publisher | Wiley Online Library | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject.classification | Catálisis asimétrica | es |
dc.subject.classification | Asymmetric catalysis | es |
dc.subject.classification | 3-Amino-oxindoles | es |
dc.subject.classification | 3-Amino-oxindoles | es |
dc.subject.classification | Pirazoles quirales | es |
dc.subject.classification | Chiral pyrazoles | es |
dc.subject.classification | Tioureas bifuncionales | es |
dc.subject.classification | Bifunctional thioureas | es |
dc.subject.classification | Reacción de Mannich | es |
dc.subject.classification | Mannich reaction | es |
dc.title | Synthesis of Enantioenriched 3-Amino-3-Substituted Oxindoles by Stereoselective Mannich Reaction Catalyzed by Supported Bifunctional Thioureas | es |
dc.type | info:eu-repo/semantics/article | es |
dc.rights.holder | © 2019 Wiley-VCH | es |
dc.identifier.doi | https://doi.org/10.1002/adsc.201900414 | es |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/full/10.1002/adsc.201900414 | es |
dc.peerreviewed | SI | es |
dc.description.project | Ministerio de Economía, Industria y Competitividad (Project FEDER-CTQ2014–59870-P) | es |
dc.description.project | Junta de Castilla y León (Projects FEDER-VA115P17 / VA149G18) | es |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 Internacional | * |
dc.type.hasVersion | info:eu-repo/semantics/acceptedVersion | es |
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