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dc.contributor.authorIbáñez Fonseca, Arturo
dc.contributor.authorFlora, Tatjana
dc.contributor.authorAcosta Rodríguez, Sergio 
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.date.accessioned2020-01-29T08:34:08Z
dc.date.available2020-01-29T08:34:08Z
dc.date.issued2019
dc.identifier.citationMatrix Biology, 2019, vol. 84. p. 111-126es
dc.identifier.issn0945-053Xes
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/40373
dc.descriptionProducción Científicaes
dc.description.abstractElastin-like recombinamers (ELRs), which derive from one of the repetitive domains found in natural elastin, have been intensively studied in the last few years from several points of view. In this mini review, we discuss all the recent works related to the investigation of ELRs, starting with those that define these polypeptides as model intrinsically disordered proteins or regions (IDPs or IDRs) and its relevance for some biomedical applications. Furthermore, we summarize the current knowledge on the development of drug, vaccine and gene delivery systems based on ELRs, while also emphasizing the use of ELR-based hydrogels in tissue engineering and regenerative medicine (TERM). Finally, we show different studies that explore applications in other fields, and several examples that describe biomaterial blends in which ELRs have a key role. This review aims to give an overview of the recent advances regarding ELRs and to encourage further investigation of their properties and applications.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationBiomaterialses
dc.subject.classificationBiomaterialeses
dc.subject.classificationElastin-like recombinamerses
dc.subject.classificationRecombinantes tipo elastinaes
dc.subject.classificationIntrinsically disordered proteinses
dc.subject.classificationProteínas intrínsecamente desestructuradases
dc.subject.classificationDrug deliveryes
dc.subject.classificationAdministración de medicamentoses
dc.subject.classificationTissue engineeringes
dc.subject.classificationIngeniería de tejidoses
dc.titleTrends in the design and use of elastin-like recombinamers as biomaterialses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2019 Elsevieres
dc.identifier.doi10.1016/j.matbio.2019.07.003es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0945053X19301520es
dc.peerreviewedSIes
dc.description.projectComisión Europea (project NMP-2014-646075)es
dc.description.projectMinisterio de Economía, Industria y Competitividad (projects PCIN-2015-010 / MAT2016-78903-R / BES-2014-069763)es
dc.description.projectJunta de Castilla y León (project VA317P18)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/submittedVersiones


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