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dc.contributor.authorPiña Lancho, María Jesús
dc.contributor.authorGirotti, Alessandra
dc.contributor.authorSerrano, Sofía
dc.contributor.authorMuñoz Martínez, Raquel 
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.contributor.authorArias Vallejo, Francisco Javier 
dc.date.accessioned2020-01-29T09:15:49Z
dc.date.available2020-01-29T09:15:49Z
dc.date.issued2020
dc.identifier.citationCancer Letters, 2020, vol. 470. p. 43-53es
dc.identifier.issn0304-3835es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/40378
dc.descriptionProducción Científicaes
dc.description.abstractThe complexity and continuous evolution of cancer make the design of novel strategies of treatment a constant challenge in biomedicine. Moreover, most of cancer treatments are still not tumor-specific and provoke high systemic toxicity. Herein we have developed a novel selective nanodevice to eliminate tumor cells while leaving healthy ones intact. To achieve this objective, a polyplex carrier, comprising an elastin like-recombinamer covalently conjugated to an aptamer and complexed with therapeutic DNA, was tested. This carrier forms a double-lock multifunctional device due to specific binding to a tumor cell marker and the selective expression of therapeutic DNA inside human breast-cancer cells. Due to the stability provided by ELRs, the homogeneous population of polyplexes obtained showed selective toxicity against cancer cells in in vitro and in vivo assay. Inhibition of tumor progression was detected early being very significant at the end point, with a dose-dependent reduction in tumor mass. Histological studies revealed a specific reduction in tumor parenchyma and in specific tumor cell markers. These results represent an important step toward the rational development of an efficient, safe and more specialized gene-delivery device for tumor therapy.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationElastin-like recombinamerses
dc.subject.classificationRecombinantes tipo elastinaes
dc.subject.classificationNanocarrierses
dc.subject.classificationNanoportadoreses
dc.subject.classificationSuicide gene therapyes
dc.subject.classificationTerapia génica suicidaes
dc.subject.classificationBreast canceres
dc.subject.classificationCáncer de mamaes
dc.titleA double safety lock tumor-specific device for suicide gene therapy in breast canceres
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2020 Elsevieres
dc.identifier.doi10.1016/j.canlet.2019.11.031es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0304383519305865es
dc.peerreviewedSIes
dc.description.projectFondo Social Europeo - FEDER- Unión Europea (project MP-2014-646075es
dc.description.projectMinisterio de Economía, Industria y Competitividad (project PCIN-2015-010 / MAT2015-68901-R / MAT2016-78903-R)es
dc.description.projectJunta de Castilla y León (project VA317P18)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/draftes


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