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dc.contributor.authorGarrote Adrados, José Antonio 
dc.contributor.authorGómez, Emma
dc.contributor.authorLeón, Alberto José
dc.contributor.authorBernardo, David
dc.contributor.authorCalvo Romero, María del Carmen
dc.contributor.authorFernández Salazar, Luis Ignacio 
dc.contributor.authorBlanco Quirós, Alfredo
dc.contributor.authorArranz Sanz, Eduardo 
dc.date.accessioned2014-01-16T12:37:55Z
dc.date.available2014-01-16T12:37:55Z
dc.date.issued2008
dc.identifier.citationDrug Target Insights, 3. p. 1-11es
dc.identifier.issn1177-3928es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/4181
dc.descriptionProducción Científicaes
dc.description.abstractThe aims of the study were to assess the usefulness of expression macroarrays to determine the pattern of expression of cytokines, chemokines and molecules related to immune system activation pathways, in non-stimulated intact intestinal tissue specimens from patients with active CD (aCD) and on a gluten-free diet (GFD), to compare it with two groups of controls with either normal or altered mucosal architecture, and to establish putative targets for diagnostic markers or therapeutic intervention. We have experienced the lack of sensitivity to detect signal of genes with low level of expression. In spite of that, active CD seems to show a Th1 cytokine pattern, but with signs of Th2 activity. Cytokines such as IL-9, IL-11, IL-21 or MIF might be involved in mucosal infl ammation in CD. In GFD, some memory cells and DC’s activity remains, and factors that maintain this remnant activation might be responsible of the fast mucosal response on gluten challenge. STAT3 and STAT5 pathways, and their regulatory molecules SOCS’s may result keys for understanding mucosal infl ammation in gut and putative targets for further research.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherInstituto de Biología y Genética Molecular (IBGM)es
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEnfermedad celíacaes
dc.titleCitokine, chemokine and immune activation pathway profiles in celiac disease : an immune system activity screening by expression macroarrays.es
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holderLibertas Academicaes
dc.identifier.publicationfirstpage1es
dc.identifier.publicationissue3es
dc.identifier.publicationlastpage11es
dc.identifier.publicationtitleDrug target insightses
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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