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dc.contributor.authorMoro Balbás, José Antonio 
dc.contributor.authorCarretero, J.
dc.contributor.authorAlonso Revuelta, María Isabel 
dc.contributor.authorMartín, C.
dc.contributor.authorGato Casado, Ángel Luis 
dc.contributor.authorMano Bonín, Anibal de la 
dc.date.accessioned2014-07-22T10:38:48Z
dc.date.available2014-07-22T10:38:48Z
dc.date.issued2008
dc.identifier.citationCitokine, XXX, 2008es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/5540
dc.descriptionProducción Científicaes
dc.description.abstractIt is known that interleukin 1b (IL-1b) and interleukin 6 (IL-6) are expressed post-natally in normal and tumoral cells in the anterior pituitary, and that they play a role in both the liberation of different hormones and in the growth, proliferation and tumor formation of the pituitary gland. However, their expression and role during embryonic and fetal development remain unknown. We have performed an immunocytochemistry study of prenatal expression and distribution of IL-1b and IL-6 in isolated embryonic rat Rathke’s pouch prior to birth, more specifically between 13.5 and 19.5 days p.c. Western-blot analysis carried out on 19.5-day p.c. embryos showed positive immunolabelling for IL-1b and IL-6. These interleukins were initially expressed simultaneously in the rostral and ventral portions of Rathke’s pouch in 15.5-day p.c. embryos, and this expression progressed caudodorsally in later developmental stages, extending to most of the hypophysis before birth. The number of cells expressing these interleukins increased throughout this period: 48.22% of anterior pituitary cells expressed IL-6 in 19.5-day embryos, whilst IL-1b was positive in 39.8% of the cells. Moreover, we have demonstrated that some adenohypophyseal cells co-express both interleukins. Such findings represent the first step towards an understanding of the physiological role of these interleukins in anterior pituitary development.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCitoquímicaes
dc.subjectHipófisis - Cánceres
dc.titlePrenatal expression of interleukin 1B and interleukin 6 in the rat pituitary glandes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.101016es
dc.identifier.publicationfirstpage1es
dc.identifier.publicationissueXXXes
dc.identifier.publicationlastpage8es
dc.identifier.publicationtitleCitokinees
dc.identifier.publicationvolumeXXXes
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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