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dc.contributor.authorGanfornina Álvarez, María Dolores 
dc.contributor.authorCarmo, Sonia do
dc.contributor.authorLora, Jose M.
dc.contributor.authorTorres-Schumann, Sonia
dc.contributor.authorVogel, Marci
dc.contributor.authorAllhorn, Maria
dc.contributor.authorGonzález, Constancio
dc.contributor.authorBastiani, Michael J.
dc.contributor.authorRassart, Eric
dc.contributor.authorSánchez Romero, Diego 
dc.date.accessioned2014-09-19T10:04:53Z
dc.date.available2014-09-19T10:04:53Z
dc.date.issued2008
dc.identifier.citationAging Cell, 2008, vol. 7, p. 506-515es
dc.identifier.issn1474-9718es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/6077
dc.descriptionProducción Científicaes
dc.description.abstractMany nervous system pathologies are associated with increased levels of apolipoprotein D (ApoD), a lipocalin also expressed during normal development and aging. An ApoD homologous gene in Drosophila , Glial Lazarillo, regulates resistance to stress, and neurodegeneration in the aging brain. Here we study for the first time the protective potential of ApoD in a vertebrate model organism. Loss of mouse ApoD function increases the sensitivity to oxidative stress and the levels of brain lipid peroxidation, and impairs locomotor and learning abilities. Human ApoD overexpression in the mouse brain produces opposite effects, increasing survival and preventing the raise of brain lipid peroxides after oxidant treatment. These observations, together with its transcriptional up-regulation in the brain upon oxidative insult, identify ApoD as an acute response protein with a protective and therefore beneficial function mediated by the control of peroxidated lipids. Key words: learning, lipid peroxidation, lipocalin, locomotor behavior, paraquat, oxidative stress.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherBlackwell Publishinges
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNervioso, sistema - Enfermedadeses
dc.subjectLípidos
dc.titleApolipoprotein D is involved in the mechanisms regulating protection from oxidative stresses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1111/j.1474-9726.2008.00395.xes
dc.identifier.publicationfirstpage506es
dc.identifier.publicationlastpage515es
dc.identifier.publicationtitleAging Celles
dc.identifier.publicationvolume7es
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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