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dc.contributor.author | Díez, Á. | |
dc.contributor.author | Suazo, V. | |
dc.contributor.author | Casado, P. | |
dc.contributor.author | Martín-Loeches, M. | |
dc.contributor.author | Molina, V. | |
dc.date.accessioned | 2024-02-28T20:45:19Z | |
dc.date.available | 2024-02-28T20:45:19Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Psychological Medicine 43(6):1175-85 | es |
dc.identifier.issn | 0033-2917 | es |
dc.identifier.uri | https://uvadoc.uva.es/handle/10324/66464 | |
dc.description.abstract | Background Brain activity is less organized in patients with schizophrenia than in healthy controls (HC). Noise power (scalp-recorded electroencephalographic activity unlocked to stimuli) may be of use for studying this disorganization. Method Fifty-four patients with schizophrenia (29 minimally treated and 25 stable treated), 23 first-degree relatives and 27 HC underwent clinical and cognitive assessments and an electroencephalographic recording during an oddball P300 paradigm to calculate noise power magnitude in the gamma band. We used a principal component analysis (PCA) to determine the factor structure of gamma noise power values across electrodes and the clinical and cognitive correlates of the resulting factors. Results The PCA revealed three noise power factors, roughly corresponding to the default mode network (DMN), frontal and occipital regions respectively. Patients showed higher gamma noise power loadings in the first factor when compared to HC and first-degree relatives. In the patients, frontal gamma noise factor scores related significantly and inversely to working memory and problem-solving performance. There were no associations with symptoms. Conclusions There is an elevated gamma activity unrelated to task processing over regions coherent with the DMN topography in patients with schizophrenia. The same type of gamma activity over frontal regions is inversely related to performance in tasks with high involvement in these frontal areas. The idea of gamma noise as a possible biological marker for schizophrenia seems promising. Gamma noise might be of use in the study of underlying neurophysiological mechanisms involved in this disease. | es |
dc.format.mimetype | application/pdf | es |
dc.language.iso | spa | es |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | es |
dc.title | Spatial distribution and cognitive correlates of gamma noise power in schizophrenia | es |
dc.type | info:eu-repo/semantics/article | es |
dc.identifier.doi | 10.1017/S0033291712002103 | es |
dc.identifier.publicationfirstpage | 1175 | es |
dc.identifier.publicationissue | 6 | es |
dc.identifier.publicationlastpage | 1185 | es |
dc.identifier.publicationtitle | Psychological Medicine | es |
dc.identifier.publicationvolume | 43 | es |
dc.peerreviewed | SI | es |
dc.identifier.essn | 1469-8978 | es |
dc.type.hasVersion | info:eu-repo/semantics/draft | es |