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Título
Biological rhythms, chrono-nutrition, and gut microbiota: Epigenomics insights for precision nutrition and metabolic health
Autor
Año del Documento
2024
Editorial
MDPI
Descripción
Producción Científica
Documento Fuente
Biomolecules, 2024, Vol. 14, Nº. 5, 559
Resumen
Circadian rhythms integrate a finely tuned network of biological processes recurring every 24 h, intricately coordinating the machinery of all cells. This self-regulating system plays a pivotal role in synchronizing physiological and behavioral responses, ensuring an adaptive metabolism within the environmental milieu, including dietary and physical activity habits. The systemic integration of circadian homeostasis involves a balance of biological rhythms, each synchronically linked to the central circadian clock. Central to this orchestration is the temporal dimension of nutrient and food intake, an aspect closely interwoven with the neuroendocrine circuit, gut physiology, and resident microbiota. Indeed, the timing of meals exerts a profound influence on cell cycle regulation through genomic and epigenetic processes, particularly those involving gene expression, DNA methylation and repair, and non-coding RNA activity. These (epi)genomic interactions involve a dynamic interface between circadian rhythms, nutrition, and the gut microbiota, shaping the metabolic and immune landscape of the host. This research endeavors to illustrate the intricate (epi)genetic interplay that modulates the synchronization of circadian rhythms, nutritional signaling, and the gut microbiota, unravelling the repercussions on metabolic health while suggesting the potential benefits of feed circadian realignment as a non-invasive therapeutic strategy for systemic metabolic modulation via gut microbiota. This exploration delves into the interconnections that underscore the significance of temporal eating patterns, offering insights regarding circadian rhythms, gut microbiota, and chrono-nutrition interactions with (epi)genomic phenomena, thereby influencing diverse aspects of metabolic, well-being, and quality of life outcomes.
Materias (normalizadas)
Circadian rhythms
Genomics
Nutrition
Biological rhythms
Ritmos biológicos
Biological Clocks - Physiology
Genomics
Genómica
Genetics
Genética humana
Environmental adaptation
Microbiota
Gut microbiota
Microbiota intestinal
Nutrition
Metabolism
Metabolismo
Public health
Materias Unesco
3206 Ciencias de la Nutrición
32 Ciencias Médicas
3212 Salud Publica
ISSN
2218-273X
Revisión por pares
SI
Patrocinador
Instituto Carlos III, Contratos Sara Borrell - (grant CD22/00011)
Comunidad Autónoma de Madrid, Consejería de Educación, CIBERobn, Instituto IMDEA Alimentación - (project METAINFLAMACION: Y2020/BIO-6600)
Comunidad Autónoma de Madrid, Consejería de Educación, CIBERobn, Instituto IMDEA Alimentación - (project METAINFLAMACION: Y2020/BIO-6600)
Version del Editor
Propietario de los Derechos
© 2024 The authors
Idioma
eng
Tipo de versión
info:eu-repo/semantics/publishedVersion
Derechos
openAccess
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