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dc.contributor.authorLiu, X.
dc.contributor.authorHe, Le
dc.contributor.authorDinger, Bruce
dc.contributor.authorGonzález, Constancio
dc.contributor.authorStensaas, L.
dc.contributor.authorFidone, Salvatore
dc.date.accessioned2014-11-04T09:39:49Z
dc.date.available2014-11-04T09:39:49Z
dc.date.issued2011
dc.identifier.citationRespiratry Physiology and Neurobiology : 2011, 178(3) 362-369es
dc.identifier.issn1569-9048es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/6890
dc.descriptionProducción Científicaes
dc.description.abstractExperiments in recent years have revealed labile electrophysiological and neurochemical phenotypes in primary afferent neurons exposed to specific stimulus conditions associated with the development of chronic pain. These studies collectively demonstrate that the mechanisms responsible for functional plasticity are primarily mediated by novel neuroimmune interactions involving circulating and resident immune cells and their secretory products, which together induce hyperexcitability in the primary sensory neurons. In another peripheral sensory modality, namely the arterial chemoreceptors, sustained stimulation in the form of chronic hypoxia (CH) elicits increased chemoafferent excitability from the mammalian carotid body. Previous studies which focused on functional changes in oxygen-sensitive type I cells in this organ have only partially elucidated the molecular and cellular mechanisms which initiate and control this adaptive response. Recent studies in our laboratory indicate a unique role for the immune system in regulating the chemo-adaptive response of the carotid body to physiologically relevant levels of hypoxia.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNeurofisiologíaes
dc.subjectDolor crónico - Tratamiento
dc.titleA chronic pain: inflammation-dependent chemoreceptor adaptation in rat carotid bodyes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1016es
dc.identifier.publicationfirstpage362es
dc.identifier.publicationissue178es
dc.identifier.publicationlastpage369es
dc.identifier.publicationtitleRespiratory Physiology and Neurobiologyes
dc.peerreviewedSIes
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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