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dc.contributor.authorGonzález de Torre, Israel 
dc.contributor.authorWeber, Miriam T.
dc.contributor.authorQuintanilla Sierra, Luis 
dc.contributor.authorAlonso Rodrigo, Matilde 
dc.contributor.authorJockenhoevel, Stefan
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.contributor.authorMela, Petra
dc.date.accessioned2016-12-15T09:25:59Z
dc.date.available2016-12-15T09:25:59Z
dc.date.issued2016
dc.identifier.citationBiomaterials Science, 2016 vol. 4, 1361-1370es
dc.identifier.issn2047-4830es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/21753
dc.descriptionProducción Científicaes
dc.description.abstractIn the field of tissue engineering, the properties of the scaffolds are of crucial importance for the success of the application. Hybrid materials combine the properties of the different components that constitute them. In this study hybrid gels of Elastin-Like Recombinamer (ELR) and fibrin were prepared with a range of polymer concentrations and ELR-to-fibrin ratios. The correlation between SEM micrographs, porosities, swelling ratios and rheological properties was discussed and a poroelastic mechanism was suggested to explain the mechanical behavior of the hybrid gels. Applicability as scaffold materials for cardiovascular tissue engineering was shown by the realization of cell-laden matrixes which supported the synthesis of collagens as revealed by immunohistochemical analysis. As a proof of concept, a tissue-engineered heart valve was fabricated by injection moulding and cultivated in a bioreactor for 3 weeks under dynamic con- ditions. Tissue analysis revealed the production of collagen I and III, fundamental proteins for cardio- vascular constructs.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherRoyal Society of Chemistryes
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectColágenoes
dc.titleHybrid elastin-like recombinamer-fibrin gels: physical characterization and in vitro evaluation for cardiovascular tissue engineering applicationses
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doi10.1039/C6BM00300Aes
dc.relation.publisherversionhttp://pubs.rsc.org/es
dc.identifier.publicationfirstpage1361es
dc.identifier.publicationissue4es
dc.identifier.publicationlastpage1370es
dc.identifier.publicationtitleBiomaterials Sciencees
dc.peerreviewedSIes
dc.description.projectJunta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA152A12-2, VA244U13 y VA155A12-2)es
dc.description.projectMinisterio de Industria, Economía y Competitividad (proyectos MAT-2010-15982, MAT2010- 15310, PRI-PIBAR-2011-1403 y MAT2012-38043-C02-01)
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/263363
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/278557
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/317304
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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