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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/21753

    Título
    Hybrid elastin-like recombinamer-fibrin gels: physical characterization and in vitro evaluation for cardiovascular tissue engineering applications
    Autor
    González de Torre, IsraelAutoridad UVA Orcid
    Weber, Miriam T.
    Quintanilla Sierra, LuisAutoridad UVA
    Alonso Rodrigo, MatildeAutoridad UVA Orcid
    Jockenhoevel, Stefan
    Rodríguez Cabello, José CarlosAutoridad UVA Orcid
    Mela, Petra
    Año del Documento
    2016
    Editorial
    Royal Society of Chemistry
    Descripción
    Producción Científica
    Documento Fuente
    Biomaterials Science, 2016 vol. 4, 1361-1370
    Résumé
    In the field of tissue engineering, the properties of the scaffolds are of crucial importance for the success of the application. Hybrid materials combine the properties of the different components that constitute them. In this study hybrid gels of Elastin-Like Recombinamer (ELR) and fibrin were prepared with a range of polymer concentrations and ELR-to-fibrin ratios. The correlation between SEM micrographs, porosities, swelling ratios and rheological properties was discussed and a poroelastic mechanism was suggested to explain the mechanical behavior of the hybrid gels. Applicability as scaffold materials for cardiovascular tissue engineering was shown by the realization of cell-laden matrixes which supported the synthesis of collagens as revealed by immunohistochemical analysis. As a proof of concept, a tissue-engineered heart valve was fabricated by injection moulding and cultivated in a bioreactor for 3 weeks under dynamic con- ditions. Tissue analysis revealed the production of collagen I and III, fundamental proteins for cardio- vascular constructs.
    Materias (normalizadas)
    Colágeno
    ISSN
    2047-4830
    Revisión por pares
    SI
    DOI
    10.1039/C6BM00300A
    Patrocinador
    Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA152A12-2, VA244U13 y VA155A12-2)
    Ministerio de Industria, Economía y Competitividad (proyectos MAT-2010-15982, MAT2010- 15310, PRI-PIBAR-2011-1403 y MAT2012-38043-C02-01)
    Patrocinador
    info:eu-repo/grantAgreement/EC/H2020/263363
    info:eu-repo/grantAgreement/EC/H2020/278557
    info:eu-repo/grantAgreement/EC/H2020/317304
    Version del Editor
    http://pubs.rsc.org/
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/21753
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP60 - Artículos de revista [113]
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    Nombre:
    Hybrid- elastin-Like-recombinamer-gels.pdf
    Tamaño:
    1.316Mo
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

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