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Por favor, use este identificador para citar o enlazar este ítem: http://uvadoc.uva.es/handle/10324/21753
Título: Hybrid elastin-like recombinamer-fibrin gels: physical characterization and in vitro evaluation for cardiovascular tissue engineering applications
Autor: González de Torre, Israel
Weber, Miriam T.
Quintanilla Sierra, Luis
Alonso Rodrigo, Matilde
Jockenhoevel, Stefan
Rodríguez Cabello, José Carlos
Mela, Petra
Año del Documento: 2016
Editorial: Royal Society of Chemistry
Descripción: Producción Científica
Documento Fuente: Biomaterials Science, 2016 vol. 4, 1361-1370
Resumen: In the field of tissue engineering, the properties of the scaffolds are of crucial importance for the success of the application. Hybrid materials combine the properties of the different components that constitute them. In this study hybrid gels of Elastin-Like Recombinamer (ELR) and fibrin were prepared with a range of polymer concentrations and ELR-to-fibrin ratios. The correlation between SEM micrographs, porosities, swelling ratios and rheological properties was discussed and a poroelastic mechanism was suggested to explain the mechanical behavior of the hybrid gels. Applicability as scaffold materials for cardiovascular tissue engineering was shown by the realization of cell-laden matrixes which supported the synthesis of collagens as revealed by immunohistochemical analysis. As a proof of concept, a tissue-engineered heart valve was fabricated by injection moulding and cultivated in a bioreactor for 3 weeks under dynamic con- ditions. Tissue analysis revealed the production of collagen I and III, fundamental proteins for cardio- vascular constructs.
Materias (normalizadas): Colágeno
ISSN: 2047-4830
Revisión por Pares: SI
DOI: 10.1039/C6BM00300A
Patrocinador: info:eu-repo/grantAgreement/EC/H2020/263363
info:eu-repo/grantAgreement/EC/H2020/278557
info:eu-repo/grantAgreement/EC/H2020/317304
Patrocinador: Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA152A12-2, VA244U13 y VA155A12-2)
Ministerio de Industria, Economía y Competitividad (proyectos MAT-2010-15982, MAT2010- 15310, PRI-PIBAR-2011-1403 y MAT2012-38043-C02-01)
Version del Editor: http://pubs.rsc.org/
Idioma: eng
URI: http://uvadoc.uva.es/handle/10324/21753
Derechos: info:eu-repo/semantics/openAccess
Aparece en las colecciones:Documentos OpenAire(Open Access Infrastructure for Research in Europe)
DEP60 - Artículos de revista

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