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dc.contributor.authorFernández Colino, Alicia
dc.contributor.authorBermúdez, J. M.
dc.contributor.authorArias Vallejo, Francisco Javier 
dc.contributor.authorQuinteros, Daniela A.
dc.contributor.authorGonzo, E.
dc.date.accessioned2017-03-29T11:30:47Z
dc.date.available2017-03-29T11:30:47Z
dc.date.issued2015
dc.identifier.citationMaterials Science and Engineering, April 2016, vol. 61, n. 1 , p. 286–292es
dc.identifier.issn0928-4931es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/22848
dc.descriptionProducción Científicaes
dc.description.abstractTransversality between mathematical modeling, pharmacology, and materials science is essential in order to achieve controlled-release systems with advanced properties. In this regard, the area of biomaterials provides a platform for the development of depots that are able to achieve controlled release of a drug, whereas pharmacology strives to find new therapeutic molecules and mathematical models have a connecting function, providing a rational understanding by modeling the parameters that influence the release observed. Herein we present a mechanism which, based on reasonable assumptions, explains the experimental data obtained very well. In addition, we have developed a simple and accurate “lumped” kinetics model to correctly fit the experimentally observed drug release behavior. This lumped model allows us to have simple analytic solutions for the mass and rate of drug release as a function of time without limitations of time or mass of drug released, which represents an important step-forward in the area of in vitro drug delivery when compared to the current state of the art in mathematical modeling. As an example, we applied the mechanism and model to the release data for acetazolamide from a recombinant polymer. Both materials were selected because of a need to develop a suitable ophthalmic formulation for the treatment of glaucoma. The in vitro release model proposed herein provides a valuable predictive tool for ensuring product performance and batch-to-batch reproducibility, thus paving the way for the development of further pharmaceutical devices.es
dc.format.mimetypeapplication/pdfes
dc.language.isospaes
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.subjectBiomateriales - Aplicaciones médicases
dc.titleDevelopment of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogeles
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttp://dx.doi.org/10.1016/j.msec.2015.12.050es
dc.peerreviewedSIes
dc.description.projectEste trabajo forma parte de los Proyectos de Investigación financiados por la Comisión Europea a través del Fondo Social Europeo (FSE) y de la Consejería de Educación mediante el Fondo Europeo de Desarrollo Regional (ERDF), el MINECO (Proyectos MAT2013-41723-R, MAT2013-42473-R, PRI−PIBAR-2011-1403 y MAT2012-38043), la Junta de Castilla y León (Proyectos VA155A12, VA152A12, and VA244U13), el CIBER-BBN y el Instituto de Salud Carlos III mediante el Centro de Medicina Regenerativa y Terapia Celular de Castilla y León.es


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