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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/23317

    Título
    Morphologic and neurochemical alterations in the superior colliculus of the genetically epilepsy-prone hamster (GPG/Vall)
    Autor
    Fuentes Santamaría, Verónica
    Alvarado, Juan Carlos
    García Atarés, María NatividadAutoridad UVA
    López, Dolores E.
    Año del Documento
    2017
    Editorial
    Elsevier
    Descripción
    Producción Científica
    Documento Fuente
    Epilepsy Research, vol.75. p.206-219
    Résumé
    The GPG/Vall hamster is an animal model that exhibits seizures in response to sound stimulation. Since the superior colliculus (SC) is implicated in the neuronal network of audiogenic seizures (AGS) in other forms of AGS, this study evaluated seizure-related anatomical or neurochemical abnormalities in the SC of the GPG/Vall hamster. This involved calbindin (CB) and parvalbumin (PV) immunohistochemistry, densitometric analysis and high performance liquid chromatography in the superficial and deep layers of the SC in control and epileptic animals. Compared to control animals, a reduction in SC volume and a hypertrophy of neurons located in the deep layers of the SC were observed in the epileptic hamster. Although, analysis of CB-immunohistochemistry in the superficial layers did not show differences between groups, analysis of PV-immunostaining in the deep SC revealed an increase in the mean gray level within immunostained neurons as well as a decreased immunostained neuropil in the GPG/Vall hamster as compared to control animals. These alterations were accompanied by a decrease in the levels of GABA and increased levels of taurine in the epileptic animal. These data indicate that the deep SC of the GPG/Vall hamster is structurally abnormal; suggesting its involvement in the neuronal network for AGS.
    Materias (normalizadas)
    Densitometría
    Hamsters
    Palabras Clave
    Epilepsia
    Revisión por pares
    SI
    DOI
    10.1016/j.eplepsyres.2007.06.005
    Propietario de los Derechos
    Elsevier
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/23317
    Derechos
    openAccess
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    • DEP04 - Artículos de revista [57]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

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