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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/27592

    Título
    Biomolecular functionalization for enhanced cell–material interactions of poly(methyl methacrylate) surfaces
    Autor
    Punet, Xavier
    Mauchauffé, Rodolphe
    Rodríguez Cabello, José CarlosAutoridad UVA Orcid
    Alonso Rodrigo, MatildeAutoridad UVA Orcid
    Engel, Elisabeth
    Mateos Timoneda, Miguel Ángel
    Año del Documento
    2015
    Editorial
    Oxford University Press
    Descripción
    Producción Científica
    Documento Fuente
    Regenerative Biomaterials, 2015, Volume 2, Issue 3, p. 167–175
    Résumé
    The integration of implants or medical devices into the body tissues requires of good cell–material interactions. However, most polymeric materials used for these applications lack on biological cues, which enhanced mid- and long-term implant failure due to weak integration with the surrounding tissue. Commonly used strategies for tissue–material integration focus on functionalization of the material surface by means of natural proteins or short peptides. However, the use of these biomolecules involves major drawbacks such as immunogenic problems and oversimplification of the constructs. Here, designed elastin-like recombinamers (ELRs) are used to enhance poly(methyl methacrylate) surface properties and compared against the use of short peptides. In this study, cell response has been analysed for different functionalization conditions in the presence and absence of a competing protein, which interferes on surface–cell interaction by unspecific adsorption on the interface. The study has shown that ELRs can induce higher rates of cell attachment and stronger cell anchorages than short peptides, being a better choice for surface functionalization.
    Palabras Clave
    Adhesión celular
    Elastina
    ISSN
    2056-3418
    Revisión por pares
    SI
    DOI
    10.1093/rb/rbv014
    Patrocinador
    Ministerio de Industria, Economía y Competitividad (proyectos MAT2008-06887-C03-01, MAT2010-15310, MAT2013-41723-R, MAT2013-42473-R y BES-2009-027524)
    Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA313U14 y VA244U13)
    Nota
    5th China-Europe Symposium on Biomaterials in Regenerative Medicine (CESB 2015) Hangzhou, China April 7–10, 2015
    Version del Editor
    https://academic.oup.com/rb/article/2/3/167/1511120?searchresult=1
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/27592
    Derechos
    openAccess
    Aparece en las colecciones
    • DEP60 - Artículos de revista [113]
    • BIOFORGE - Artículos de revista [89]
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    Attribution-NonCommercial-NoDerivatives 4.0 InternationalExcepté là où spécifié autrement, la license de ce document est décrite en tant que Attribution-NonCommercial-NoDerivatives 4.0 International

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