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Título
Biomolecular functionalization for enhanced cell–material interactions of poly(methyl methacrylate) surfaces
Autor
Año del Documento
2015
Editorial
Oxford University Press
Descripción
Producción Científica
Documento Fuente
Regenerative Biomaterials, 2015, Volume 2, Issue 3, p. 167–175
Resumo
The integration of implants or medical devices into the body tissues requires of good cell–material interactions. However, most polymeric materials used for these applications lack on biological cues, which enhanced mid- and long-term implant failure due to weak integration with the surrounding tissue. Commonly used strategies for tissue–material integration focus on functionalization of the material surface by means of natural proteins or short peptides. However, the use of these biomolecules involves major drawbacks such as immunogenic problems and oversimplification of the constructs. Here, designed elastin-like recombinamers (ELRs) are used to enhance poly(methyl methacrylate) surface properties and compared against the use of short peptides. In this study, cell response has been analysed for different functionalization conditions in the presence and absence of a competing protein, which interferes on surface–cell interaction by unspecific adsorption on the interface. The study has shown that ELRs can induce higher rates of cell attachment and stronger cell anchorages than short peptides, being a better choice for surface functionalization.
Palabras Clave
Adhesión celular
Elastina
ISSN
2056-3418
Revisión por pares
SI
Patrocinador
Ministerio de Industria, Economía y Competitividad (proyectos MAT2008-06887-C03-01, MAT2010-15310, MAT2013-41723-R, MAT2013-42473-R y BES-2009-027524)
Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA313U14 y VA244U13)
Junta de Castilla y León (programa de apoyo a proyectos de investigación – Ref. VA313U14 y VA244U13)
Nota
5th China-Europe Symposium on Biomaterials in Regenerative Medicine (CESB 2015) Hangzhou, China April 7–10, 2015
Version del Editor
Idioma
eng
Derechos
openAccess
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