Prevalence of TERT promoter mutations in Anaplastic Thiroid Carcinomas. Concurrent activation of TERT and MAPK signalling pathway

Abstract

As it is known, cancer is defined as an uncontrolled growth of cells in a located part of the body. The problem starts when, from a normal division of cells, an alteration occurs that provokes this abnormal growth, and ends in a mass of cells (Tumour). It can occur that the system acts repairing this situation, by causing apoptosis in those transformed cells, so they would die. However, in case the damage cannot be repaired, they would keep on growing and invading other organs or tissues leading to local or distant metastasis