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dc.contributor.authorGonzález de Torre, Israel 
dc.contributor.authorIbáñez Fonseca, Arturo
dc.contributor.authorQuintanilla Sierra, Luis 
dc.contributor.authorAlonso Rodrigo, Matilde 
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.date.accessioned2018-12-13T09:58:15Z
dc.date.available2018-12-13T09:58:15Z
dc.date.issued2018
dc.identifier.citationActa Biomaterialia, 2018, Volume 72, Pages 137-149es
dc.identifier.issn1742-7061es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/33443
dc.descriptionProducción Científicaes
dc.description.abstractHerein we present a system to obtain fibers from clickable elastin-like recombinamers (ELRs) that crosslink in situ during the electrospinning process itself, with no need for any further treatment to stabilize them. These ELR-click fibers are completely stable under in vitro conditions. A wrinkled fiber morphology is obtained. In addition to a random fiber orientation, oriented fibers with a high degree of alignment and coherence can also be obtained by using a rotational electrode. The production of multicomponent fibers means that different functionalities, such as cell-adhesion domains (RGD peptides), can be incorporated into them. In a subsequent study, two main cell lines present in the dermis and epidermis, namely keratinocytes and fibroblasts, were cultured on top of the ELR-click fibers. Adhesion, proliferation, fluorescence, immunostaining and histology studies showed the cytocompatibility of these scaffolds, thus suggesting their possible use for wound dressings in skin tissue engineering applications.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.classificationElastinaes
dc.subject.classificationIngeniería de tejidos dérmicoses
dc.subject.classificationElastines
dc.subject.classificationDermal tissue engineeringes
dc.titleRandom and oriented electrospun fibers based on a multicomponent, in situ clickable elastin-like recombinamer system for dermal tissue engineeringes
dc.typeinfo:eu-repo/semantics/articlees
dc.identifier.doihttps://doi.org/10.1016/j.actbio.2018.03.027es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1742706118301478es
dc.peerreviewedSIes
dc.description.projectMinisterio de Economía, Industria y Competitividad (Projects MAT2015-68901-R, MAT2016-78903-R, PCIN-2015-010)es
dc.description.projectJunta de Castilla y León (programa de apoyo a proyectos de investigación - Ref. VA015U16)es
dc.description.projectEuropean Commission (ELASTISLET No 646075, BIOGEL No 642687)es
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/646075
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/642687
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International


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