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dc.contributor.authorGarcía Couce, Jomarien
dc.contributor.authorCampos, Yaima
dc.contributor.authorTorres, Susana
dc.contributor.authorPeón, Eduardo
dc.contributor.authorFuentes, Gastón
dc.contributor.authorAlmirall, Amisel
dc.contributor.authorDelgado, José Ángel
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.contributor.authorCruz Ricondo, Luis J.
dc.date.accessioned2019-04-03T12:06:36Z
dc.date.issued2018
dc.identifier.citationPolymer, 2018, vol. 158. p. 279-288es
dc.identifier.issn0032-3861es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/35329
dc.descriptionProducción Científicaes
dc.description.abstractHydrophilic composites of poly (acrylamide-co-2-hydroxyethyl methacrylate) reinforced with hydroxyapatite were synthesized, characterized and evaluated as drug delivery systems. The results show a strong dependence of the polymer composition, the degree of crosslinking and the homogeneity of the particles dispersion (filler or the mixed drug) in the characteristics that were analyzed. The mechanical properties were better while the swelling and the diffusion coefficient were worse than hydrogels with cefazolin of similar compositions. Additionally, a new information criterion was used to elucidate the best fit. The drug diffusion into the medium was anomalous with a tendency towards Case II transport, indicating that under certain conditions zero-order diffusion could be achieved. This fact suggests that these materials could be used in the manufacture of medical devices for the controlled delivery of drugs and active or biological principles, significantly improving therapeutic procedures today.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.subject.classificationCriterio de informaciónes
dc.subject.classificationInformation criteriones
dc.subject.classificationAdministración de medicamentoses
dc.subject.classificationDrug deliveryes
dc.subject.classificationPoliacrilamidaes
dc.subject.classificationPolyacrylamidees
dc.titleA novel information criterion to elucidate a drug delivery mechanism from poly (acrylamide-co-2-hydroxyethyl methacrylate) reinforced with hydroxyapatite compositees
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2019 Elsevieres
dc.identifier.doihttps://doi.org/10.1016/j.polymer.2018.10.068es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0032386118309959es
dc.peerreviewedSIes
dc.description.embargo2020-12-06es
dc.description.lift2020-12-06
dc.description.projectEuropean Union (Erasmus PLUS project NL01-KA 107-008639; Erasmus MUNDUS LINDO ML14PD1157)es


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