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dc.contributor.authorFernández Colino, Alicia
dc.contributor.authorWolf, Frederic
dc.contributor.authorMoreira, Ricardo
dc.contributor.authorRütten, Stephan
dc.contributor.authorSchmitz-Rode, Thomas
dc.contributor.authorRodríguez Cabello, José Carlos 
dc.contributor.authorJockenhoevel, Stefan
dc.contributor.authorMela, Petra
dc.date.accessioned2020-01-29T08:20:30Z
dc.date.available2020-01-29T08:20:30Z
dc.date.issued2019
dc.identifier.citationEuropean Polymer Journal, 2019, vol. 121. 20 p.es
dc.identifier.issn0014-3057es
dc.identifier.urihttp://uvadoc.uva.es/handle/10324/40371
dc.descriptionProducción Científicaes
dc.description.abstractCoronary artery disease is the leading cause of death around the world. Endovascular stenting is the preferred treatment option to restore blood flow in the coronary arteries due to the lower perioperative morbidity when compared with more invasive treatment options. However, stent failure is still a major clinical problem, and further technological solutions are required to improve the performance of current stents. Here, we developed coronary stents covered with elastin-like recombinamers (ELRs) by exploiting a layer-by-layer technique combined with catalyst-free click chemistry. The resulting ELR-covered stents were intact after an in vitro simulated implantation procedure by balloon dilatation, which evidenced the elastic performance of the membrane. Additionally, the stents were mechanically stable under high flow conditions, which is in agreement with the covalent and stable nature of the click chemistry crosslinking strategy exploited during the ELR-membrane manufacturing and the successful embedding of the stent. Minimal platelet adhesion was detected after blood exposure in a Chandler loop as shown by scanning electron microscopy. The seeding of human endothelial progenitor cells (EPCs) on the ELR-membranes resulted in a confluent endothelial layer. These results prove the potential of this strategy to develop an advanced generation of coronary stents, with a stable and bioactive elastin-like membrane to exclude the atherosclerotic plaque from the blood stream or to seal coronary perforations and aneurysms, while providing a luminal surface with minimal platelet adhesion and favouring endothelialization.es
dc.format.mimetypeapplication/pdfes
dc.language.isoenges
dc.publisherElsevieres
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subject.classificationCoronary stentses
dc.subject.classificationStents coronarioses
dc.subject.classificationElastin-like recombinamerses
dc.subject.classificationRecombinantes tipo elastinaes
dc.subject.classificationClick chemistryes
dc.subject.classificationQuímica clickes
dc.subject.classificationHemocompatibilityes
dc.subject.classificationHemocompatibilidades
dc.titleLayer-by-layer biofabrication of coronary covered stents with clickable elastin-like recombinamerses
dc.typeinfo:eu-repo/semantics/articlees
dc.rights.holder© 2019 Elsevieres
dc.identifier.doi10.1016/j.eurpolymj.2019.109334es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0014305719313035es
dc.peerreviewedSIes
dc.description.projectGerman federal and state governments (project StUpPD_330-18)es
dc.description.projectMinisterio de Economía, Industria y Competitividad (projects PCIN-2015-010 / MAT2016-78903-R)es
dc.description.projectJunta de Castilla y León (project VA317P18)es
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.type.hasVersioninfo:eu-repo/semantics/submittedVersiones


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