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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/40639

    Título
    Biomarkers in ocular chronic graft versus host disease: tear cytokine- and chemokine-based predictive model.
    Autor
    Cocho Archiles, LidiaAutoridad UVA Orcid
    Fernández Martínez, ItziarAutoridad UVA Orcid
    Calonge, MargaritaAutoridad UVA Orcid
    Martínez, Verónica
    González García, María JesúsAutoridad UVA Orcid
    Caballero, Dolores
    López Corral, Lucía
    García Vázquez, Carmen
    Vázquez, Lourdes
    Stern, Michael E.
    Enriquez De Salamanca Aladro, AmaliaAutoridad UVA Orcid
    Año del Documento
    2016
    Editorial
    ARVO JOURNALS
    Descripción
    Producción Científica
    Documento Fuente
    Invest Ophthalmol Vis Sci. 2016 Feb;57(2):746-58
    Zusammenfassung
    Purpose: To develop a tear molecule level-based predictive model based on a panel of tear cytokines and their correlation with clinical features in ocular chronic graft versus host disease (cGVHD). Methods: Twenty-two ocular cGVHD patients and 21 healthy subjects were evaluated in a controlled environmental research laboratory (CERLab). Clinical parameters were recorded, and tears were collected. Levels of 15 molecules (epidermal growth factor [EGF], IL receptor antagonist [IL-1Ra], IL-1β, IL-2, IL-6, IL-8/CXCL8, IL-10, IL-12p70, IL-17A, interferon inducible protein [IP]-10/CXCL10, IFN-γ, VEGF, TNF-α, eotaxin 1, and regulated on activation normal T cell expressed and secreted [RANTES]) were measured by multiplex-bead assay and correlated with clinical parameters. Logistic regression was used to develop a predictive model. Leave-one-out cross-validation was applied. Classification capacity was evaluated in a cohort of individuals with dry eye (DE) of other etiologies different from GVHD. Results: Epidermal growth factor and IP-10/CXCL10 levels were significantly decreased in ocular cGVHD, positively correlating with tear production and stability and negatively correlating with symptoms, hyperemia, and vital staining. Interleukin-1Ra, IL-8/CXCL8, and IL-10 were significantly increased in ocular cGVHD, and the first two correlated positively with symptoms, hyperemia, and ocular surface integrity while negatively correlating with tear production and stability. Predictive models were generated, and the best panel was based on IL-8/CXCL8 and IP-10/CXCL10 tear levels along with age and sex, with an area under the receiving operating curve of 0.9004, sensitivity of 86.36%, and specificity of 95.24%. Conclusions: A predictive model based on tear levels of IL-8/CXCL8 and IP-10/CXCL10 resulted in optimal sensitivity and specificity. These results add further knowledge to the search for potential biomarkers in this devastating ocular inflammatory disease.
    Palabras Clave
    Biomarcadores
    ISSN
    1552-5783
    Revisión por pares
    SI
    DOI
    10.1167/iovs.15-18615
    Patrocinador
    Ministry of Economy and Competitiveness, Madrid, Spain, SAF-2010 15631 (AES).
    Version del Editor
    https://iovs.arvojournals.org/article.aspx?articleid=2498955#117845204
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/40639
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Aparece en las colecciones
    • IOBA - Artículos de revista [80]
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    Dateien zu dieser Ressource
    Nombre:
    Cocho L et al IOVS 2016.pdf
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    1.392Mb
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