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    Por favor, use este identificador para citar o enlazar este ítem:http://uvadoc.uva.es/handle/10324/44591

    Título
    K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation
    Autor
    Cidad Velasco, María Del PilarAutoridad UVA Orcid
    Novensá, Laura
    Garabito, M.
    Batlle, M.
    Dantas, A. P.
    Heras i Fortuny, Maria Magdalena
    López López, José RamónAutoridad UVA Orcid
    Pérez García, María TeresaAutoridad UVA Orcid
    Roqué, Mercé
    Año del Documento
    2014
    Editorial
    Springer Link
    Descripción
    Producción Científica
    Documento Fuente
    Cardiovascular Drugs and Therapy, 2014, vol. 28. p. 501-511
    Abstract
    K+ channels are central to vascular pathophysiology. Previous results demonstrated that phenotypic modulation associates with a change in Kv1.3 to Kv1.5 expression, and that Kv1.3 blockade inhibits proliferation of VSMCs cultures. Purpose: To explore whether the Kv1.3 to Kv1.5 switch could be a marker of the increased risk of intimal hyperplasia in essential hypertension and whether systemic treatment with Kv1.3 blockers can prevent intimal hyperplasia after endoluminal lesion . Methods: Morphometric and immunohistochemical analysis were performed in arterial segments following arterial injury and constant infusion of the Kv1.3 blocker PAP-1 during 28 days. Differential expression of K+ channel genes was studied in VSMC from hypertensive (BPH) and normotensive (BPN) mice, both in control and after endoluminal lesion. Finally, the migration and proliferation rate of BPN and BPH VSMCs was explored in vitro. Results: Changes in mRNA expression led to an increased Kv1.3/Kv1.5 ratio in BPH VSMC. Consistent with this, arterial injury in BPH mice induced a higher degree of luminal stenosis, (84±4 % vs. 70±5 % in BPN, p<0.01), although no differences in migration and proliferation rate were observed in cultured VSMCs. The in vivo proliferative lesions were significantly decreased upon PAP-1 systemic infusion (18± 6 % vs. 58±20 % with vehicle, p<0.05). Conclusions: Hypertension leads to a higher degree of luminal stenosis in our arterial injury model, that correlates with a decreased expression of Kv1.5 channels. Kv1.3 blockers decreased in vitro VSMCs proliferation, migration, and in vivo intimal hyperplasia formation, pointing to Kv1.3 channels as promising therapeutical targets against restenosis.
    Palabras Clave
    Potassium channels
    Canales de potasio
    Intimal hyperplasia
    Hiperplasia intimal
    Hypertension
    Hipertensión
    ISSN
    1573-7241
    Revisión por pares
    SI
    DOI
    10.1007/s10557-014-6554-5
    Patrocinador
    Ministerio de Economía, Industria y Competitividad (project RD12/0042/0006)
    Fondo de Investigación en Salud - Instituto Carlos III (project PI11/00225)
    VALTEC 09-1-0042
    Ministerio de Ciencia, Innovación y Universidades (grant BFU2010-15898)
    Junta de Castilla y León (grant VA094A11-2)
    Nota
    La versión original del artículo contiene un error. El gráfico de la página 505 es incorrecto. La corrección del mismo se encuentra en el segundo fichero "Erratum to: K+ Channels Expression in Hypertension After Arterial Injury, and Effect of Selective Kv1.3 Blockade with PAP-1 on Intimal Hyperplasia Formation".
    Version del Editor
    https://link.springer.com/article/10.1007/s10557-014-6554-5
    Propietario de los Derechos
    © 2014 Springer
    Idioma
    eng
    URI
    http://uvadoc.uva.es/handle/10324/44591
    Tipo de versión
    info:eu-repo/semantics/publishedVersion
    Derechos
    openAccess
    Collections
    • DEP06 - Artículos de revista [352]
    • IBGM - Artículos de revista [78]
    • VASCUMIT - Artículos de revista [47]
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    Attribution-NonCommercial-NoDerivs 3.0 UnportedExcept where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Unported

    Universidad de Valladolid

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